| Week | Add | Drop |
| Pre-Season |
Round 2: SP Clarke Schmidt - NYA Round A: SP Shota Imanaga - ChN Round B: OF Roman Anthony - Bos |
Round A: OF Charlie Blackmon - Col |
| Week 1 |
Round 1: RP Abner Uribe - Mil Round 2: RP Ronel Blanco - Hou | |
| Week 2 |
Round 1: SP Paul Blackburn - Oak Round 2: SP Sean Manaea - NYN |
Round 1: SP Nick Lodolo - Cin Round 2: OF Sal Frelick - Mil |
| Week 3 |
Round 1: SP Martin Perez - Pit |
Round 1: 1B Jose Abreu - Hou |
| Week 4 |
Round 1: OF Esteury Ruiz - Oak |
Round 1: RP Abner Uribe - Mil |
| Week 5 |
Round 1: OF Mark Canha - Det Round 2: SP Trevor Williams - Was |
Round 1: OF Esteury Ruiz - Oak Round 2: OF Walker Jenkins - Min |
| Week 6 |
Round 1: 2B Luis Rengifo - LAA |
Round 1: OF Mark Canha - Det |
| Week 7 |
Round 1: SP Hayden Wesneski - ChN Round 2: SP Alek Manoah - Tor |
Round 1: 1B Nolan Schanuel - LAA Round 2: SP Hayden Wesneski - ChN |
| 1st Team | 2nd Team |
| Pre-Season | |
| Lehigh Valley Iron Pigs | Chattanooga Lookouts |
|
SS
Jordan Lawlar
Ari |
C
Will Smith
LAD |
| Pre-Season | |
| Lehigh Valley Iron Pigs | Rounding Third |
|
2B
Matt McLain
Cin OF Wyatt Langford Tex |
2B
Marcus Semien
Tex SP Logan Webb SF RP David Bednar Pit Round 5, 9th Pick (SP Kyle Bradish Bal) |
| Pre-Season | |
| Lehigh Valley Iron Pigs | Bottom of the pack 5 |
|
OF
Dylan Crews
Was 3B Coby Mayo Bal |
Round 4, 2nd Pick (OF Lane Thomas Was) Round 6, 2nd Pick (OF Cedric Mullins Bal) |
| Pre-Season | |
| Lehigh Valley Iron Pigs | Bottom of the pack 5 |
|
3B
Royce Lewis
Min 1B Triston Casas Bos OF Corbin Carroll Ari |
3B
Manny Machado
SD SS Corey Seager Tex OF Luis Robert ChA Round 7, 2nd Pick (1B Jose Abreu Hou) |
| Pre-Season | |
| Lehigh Valley Iron Pigs | Rounding Third |
|
Round 9, 3rd Pick (OF Jarred Kelenic Atl) |
SS
C.J. Abrams
Was |
| Pre-Season | |
| Lehigh Valley Iron Pigs | Chattanooga Lookouts |
|
C
Yan Gomes
ChN |
Round 3, 8th Pick (SS C.J. Abrams Was) |
| Pre-Season | |
| Lehigh Valley Iron Pigs | The Plantation |
|
1B
Seth Brown
Oak |
Round 6, 10th Pick (SP Kodai Senga NYN) |
| Pre-Season | |
| Lehigh Valley Iron Pigs | Santa Fe Fuego |
|
Round 18, 2nd Pick (C Elias Diaz Col) Round 19, 2nd Pick (RP Will Smith KC) Round 17, 3rd Pick (OF Brenton Doyle Col) Round 18, 3rd Pick (1B Ty France Sea) Round 19, 3rd Pick (3B D.J. LeMahieu NYA) |
Round 12, 5th Pick (SP Nick Lodolo Cin) |
| Pre-Season | |
| Lehigh Valley Iron Pigs | Bottom of the pack 5 |
|
2B
Nolan Gorman
StL |
RP
Edwin Diaz
NYN |
| Pre-Season | |
| Lehigh Valley Iron Pigs | Bottom of the pack 5 |
|
Round 2, 3rd Pick (RP Evan Phillips LAD) Round 6, 10th Pick (SP Kodai Senga NYN) |
1B
Triston Casas
Bos Round 18, 2nd Pick (C Elias Diaz Col) Round 19, 2nd Pick (RP Will Smith KC) |
| Week 6 | |
| Lehigh Valley Iron Pigs | Pollock's Cuban Stars |
|
SP
Martin Perez
Pit 3B Manny Machado SD SP Sean Manaea NYN SS Corey Seager Tex 3B Ke'Bryan Hayes Pit C Logan O'Hoppe LAA |
SP
Zach Wheeler
Phi SS Trea Turner Phi SP Reynaldo Lopez Atl OF Eloy Jimenez ChA OF Alex Verdugo NYA 3B Isaac Paredes TB |
| Week 7 | |
| Lehigh Valley Iron Pigs | Pollock's Cuban Stars |
|
OF
Lane Thomas
Was |
C
Danny Jansen
Tor |
| Week 7 | |
| Lehigh Valley Iron Pigs | Bottom of the pack 5 |
|
SS
C.J. Abrams
Was |
RP
Raisel Iglesias
Atl 1B Triston Casas Bos |