| Week | Add | Drop |
| Pre-Season |
Round 1: RP Kevin Ginkel - Ari Round 2: OF Dominic Canzone - Sea Round A: SP Jacob deGrom - Tex |
Round A: C Travis d'Arnaud - Atl |
| Week 1 |
Round 2: 1B Jared Walsh - ChA | |
| Week 2 |
Round 1: SP Tanner Houck - Bos Round 2: OF Connor Joe - Pit | |
| Week 3 |
Round 1: 2B Brice Turang - Mil Round 2: C Ivan Herrera - StL | |
| Week 4 |
Round 1: RP Kirby Yates - Tex |
Round 1: SP Ryne Nelson - Ari |
| Week 5 |
Round 1: OF Wilyer Abreu - Bos Round 2: 3B Tyler Black - Mil |
Round 1: OF Dominic Canzone - Sea Round 2: 3B Anthony Rendon - LAA |
| Week 6 |
Round 1: OF Jordan Beck - Col |
Round 1: RP Kevin Ginkel - Ari Round 2: 1B Kris Bryant - Col |
| 1st Team | 2nd Team |
| Pre-Season | |
| Chattanooga Lookouts | Lehigh Valley Iron Pigs |
|
C
Will Smith
LAD |
SS
Jordan Lawlar
Ari |
| Pre-Season | |
| Chattanooga Lookouts | 5 Gamers |
|
Round 13, 8th Pick (SP Shane McClanahan TB) |
Round 16, 4th Pick (SS Paul DeJong ChA) Round 17, 4th Pick (3B Patrick Wisdom ChN) Round 17, 7th Pick (3B Ezequiel Duran Tex) |
| Pre-Season | |
| Chattanooga Lookouts | Rounding Third |
|
Round 8, 8th Pick (SP Michael King SD) |
SP
Logan Gilbert
Sea |
| Pre-Season | |
| Chattanooga Lookouts | Bottom of the pack 5 |
|
Round 6, 8th Pick (2B Jonathan India Cin) |
OF
Dylan Crews
Was |
| Pre-Season | |
| Chattanooga Lookouts | Bottom of the pack 5 |
|
Round 2, 8th Pick (RP Adbert Alzolay ChN) |
RP
Peter Fairbanks
TB |
| Pre-Season | |
| Chattanooga Lookouts | Lehigh Valley Iron Pigs |
|
Round 3, 8th Pick (SS C.J. Abrams Was) |
C
Yan Gomes
ChN |
| Pre-Season | |
| Chattanooga Lookouts | 5 Gamers |
|
Round 5, 8th Pick (2B Edouard Julien Min) Round 11, 8th Pick (OF Lourdes Gurriel Ari) |
Round 18, 4th Pick (1B Matt Mervis ChN) Round 19, 4th Pick (RP Michael Kopech ChA) |
| Pre-Season | |
| Chattanooga Lookouts | Santa Fe Fuego |
|
Round 4, 8th Pick (SP Gavin Williams Cle) |
C
Freddy Fermin
KC |
| Pre-Season | |
| Chattanooga Lookouts | Santa Fe Fuego |
|
Round 7, 8th Pick (OF Matt Wallner Min) |
SS
J.P. Crawford
Sea |
| Pre-Season | |
| Chattanooga Lookouts | 5 Gamers |
|
SS
Willy Adames
Mil |
Round 9, 4th Pick (DH J.D. Martinez NYN) |
| Week 5 | |
| Chattanooga Lookouts | Rounding Third |
|
RP
Alexis Diaz
Cin |
SP
Jared Jones
Pit |