| Week | Add | Drop |
| Pre-Season |
Round 1: RP Kyle Finnegan - Was Round 2: SP Trevor Rogers - Mia Round A: SP Jacob deGrom - Tex Round B: SP John Means - Bal |
Round A: 1B Ty France - Sea Round B: 1B LaMonte Wade Jr - SF |
| Week 1 |
Round 2: 1B Rowdy Tellez - Pit | |
| Week 2 |
Round 1: SP Dane Dunning - Tex Round 2: OF Connor Joe - Pit | |
| Week 3 |
Round 1: SP Tyler Anderson - LAA Round 2: OF Joey Loperfido - Hou |
Round 1: SP Shane Bieber - Cle Round 2: OF TJ Friedl - Cin |
| Week 4 |
Round 1: OF Andy Pages - LAD |
Round 1: C Alejandro Kirk - Tor |
| Week 5 |
Round 1: 3B Orelvis Martinez - Tor Round 2: SP Landon Knack - LAD |
Round 1: OF Aaron Hicks - LAA Round 2: C Tyler Stephenson - Cin |
| Week 6 |
Round 1: OF Mike Tauchman - ChN Round 2: RP Tanner Scott - Mia |
Round 1: RP Will Smith - KC Round 2: 1B Rowdy Tellez - Pit |
| Week 7 |
Round 1: SP Erick Fedde - ChA |
Round 1: SP Dane Dunning - Tex |
| 1st Team | 2nd Team |
| Pre-Season | |
| Knoxville Giants | Horseheads Buffalos |
|
Round 11, 5th Pick (2B Jordan Westburg Bal) |
SS
Willy Adames
Mil |
| Pre-Season | |
| Knoxville Giants | Chaos Creators |
|
Round 8, 5th Pick (SS Ha-seong Kim SD) |
SP
Brayan Bello
Bos |
| Pre-Season | |
| Knoxville Giants | 20 GAMERS |
|
RP
Scott McGough
Ari |
Round 3, 10th Pick (SP Tanner Bibee Cle) |
| Pre-Season | |
| Knoxville Giants | Chaos Creators |
|
OF
Brent Rooker
Oak |
Round 4, 8th Pick (SP Gavin Williams Cle) |
| Pre-Season | |
| Knoxville Giants | 20 GAMERS |
|
Round 5, 5th Pick (RP Clay Holmes NYA) |
SS
Masyn Winn
StL |
| Week 3 | |
| Knoxville Giants | 20 GAMERS |
|
OF
Giancarlo Stanton
NYA 3B Ryan McMahon Col |
SS
Gavin Lux
LAD OF Jordan Walker StL |