| Week | Add | Drop |
| Pre-Season |
Round 2: SP Tylor Megill - NYN | |
| Week 1 |
Round 1: OF Starling Marte - NYN Round 2: SP Dane Dunning - Tex | |
| Week 5 |
Round 1: OF Brandon Marsh - Phi Round 2: SP Bailey Falter - Pit |
Round 1: SP J.P. France - Hou Round 2: SP Tylor Megill - NYN |
| Week 6 |
Round 1: RP Hector Neris - ChN Round 2: 3B Patrick Wisdom - ChN |
Round 1: RP Adbert Alzolay - ChN Round 2: SP Eury Perez - Mia |
| 1st Team | 2nd Team |
| Pre-Season | |
| Cole's American Giants | Jamestown Jammers |
|
OF
Wyatt Langford
Tex |
Round 2, 1st Pick (OF Christopher Morel ChN) Round 10, 1st Pick (SP Bryce Miller Sea) |
| Pre-Season | |
| Cole's American Giants | Las Vegas MGM |
|
SP
Chase Silseth
LAA |
Round 1, 12th Pick (1B Nate Lowe Tex) |
| Pre-Season | |
| Cole's American Giants | The Plantation |
|
1B
Jake Cronenworth
SD |
Round 1, 11th Pick (SP Blake Snell SF) |
| Pre-Season | |
| Cole's American Giants | The Plantation |
|
OF
Tommy Pham
F/A |
Round 6, 11th Pick (SP Sonny Gray StL) |
| Pre-Season | |
| Cole's American Giants | Chaos Creators |
|
OF
Charlie Blackmon
Col |
Round 2, 7th Pick (C J.T. Realmuto Phi) Round 5, 7th Pick (2B Brandon Lowe TB) |
| Pre-Season | |
| Cole's American Giants | 18 Gamers |
|
Round 9, 5th Pick (SP Hunter Brown Hou) |
SP
Kyle Harrison
SF |
| Pre-Season | |
| Cole's American Giants | The Shogun of Harlem |
|
Round 3, 5th Pick (SP Chris Sale Atl) |
RP
Josh Hader
Hou |
| Week 7 | |
| Cole's American Giants | Las Vegas MGM |
|
SP
Sonny Gray
StL C J.T. Realmuto Phi SP Jose Berrios Tor SS Willy Adames Mil 1B Nate Lowe Tex 2B Nico Hoerner ChN OF Christopher Morel ChN |
SP
Gerrit Cole
NYA RP Devin Williams Mil SS Anthony Volpe NYA C Ivan Herrera StL OF Michael Harris Atl OF Pete Crow-Armstrong ChN OF Sal Frelick Mil |