| Week | Add | Drop |
| Pre-Season |
Round 1: RP Kevin Ginkel - Ari Round 2: 3B Curtis Mead - TB Round A: SP Yoshinobu Yamamoto - LAD Round B: C Bo Naylor - Cle |
Round A: SS Tim Anderson - Mia Round B: SP Taj Bradley - TB |
| Week 1 |
Round 1: OF Michael Conforto - SF Round 2: SP Tanner Houck - Bos | |
| Week 2 |
Round 1: SP Max Meyer - Mia Round 2: 2B Brice Turang - Mil |
Round 2: C Shea Langeliers - Oak |
| Week 4 |
Round 1: SP Mike Lorenzen - Tex |
Round 1: 1B Kris Bryant - Col |
| Week 5 |
Round 1: OF Wilyer Abreu - Bos Round 2: 3B Orelvis Martinez - Tor |
Round 1: 2B Bryson Stott - Phi Round 2: 1B Ryan Noda - Oak |
| Week 6 |
Round 1: 3B Tyler Black - Mil |
Round 1: SP Jordan Wicks - ChN |
| 1st Team | 2nd Team |
| Pre-Season | |
| Jamestown Jammers | Navigators |
|
Round 8, 1st Pick (3B Maikel Garcia KC) |
1B
Josh Naylor
Cle |
| Pre-Season | |
| Jamestown Jammers | Cole's American Giants |
|
Round 2, 1st Pick (OF Christopher Morel ChN) Round 10, 1st Pick (SP Bryce Miller Sea) |
OF
Wyatt Langford
Tex |
| Pre-Season | |
| Jamestown Jammers | Chaos Creators |
|
3B
Rafael Devers
Bos SS Bobby Witt Jr. KC |
OF
Fernando Tatis Jr.
SD SS Bo Bichette Tor |
| Pre-Season | |
| Jamestown Jammers | Las Vegas MGM |
|
1B
Ryan O'Hearn
Bal |
Round 5, 12th Pick (OF Jarren Duran Bos) |
| Pre-Season | |
| Jamestown Jammers | The Shogun of Harlem |
|
SP
Bobby Miller
LAD |
3B
Coby Mayo
Bal |