| Week | Add | Drop |
| Pre-Season |
Round 1: SP Graham Ashcraft - Cin Round 2: OF Nelson Velazquez - KC Round A: OF Hunter Goodman - Col |
Round A: C Endy Rodriguez - Pit |
| Week 1 |
Round 1: RP Hunter Harvey - Was Round 2: 3B Jared Triolo - Pit | |
| Week 2 |
Round 1: SP Paul Blackburn - Oak Round 2: SP Sean Manaea - NYN | |
| Week 3 |
Round 1: C Ivan Herrera - StL Round 2: SP Matt Manning - Det |
Round 2: RP Jose Leclerc - Tex |
| Week 4 |
Round 1: 1B Ryan O'Hearn - Bal Round 2: SS Blaze Alexander - Ari |
Round 1: SP Ricky Tiedemann - Tor Round 2: C Gary Sanchez - Mil |
| Week 5 |
Round 1: OF Pete Crow-Armstrong - ChN Round 2: OF Mark Canha - Det |
Round 1: OF Parker Meadows - Det Round 2: 1B Jose Abreu - Hou |
| Week 6 |
Round 1: SP Trevor Williams - Was Round 2: OF Brent Rooker - Oak |
Round 1: RP Hunter Harvey - Was Round 2: SP Matt Manning - Det |
| 1st Team | 2nd Team |
| Pre-Season | |
| Las Vegas MGM | 18 Gamers |
|
OF
Kyle Schwarber
Phi |
Round 1, 2nd Pick (SP Freddy Peralta Mil) Round 6, 2nd Pick (SP Kyle Bradish Bal) |
| Pre-Season | |
| Las Vegas MGM | Chaos Creators |
|
Round 8, 12th Pick (SS Jackson Merrill SD) |
SS
Anthony Volpe
NYA |
| Pre-Season | |
| Las Vegas MGM | 18 Gamers |
|
C
William Contreras
Mil |
SP
Grayson Rodriguez
Bal |
| Pre-Season | |
| Las Vegas MGM | Jamestown Jammers |
|
Round 5, 12th Pick (OF Jarren Duran Bos) |
1B
Ryan O'Hearn
Bal |
| Pre-Season | |
| Las Vegas MGM | Cole's American Giants |
|
Round 1, 12th Pick (1B Nate Lowe Tex) |
SP
Chase Silseth
LAA |
| Pre-Season | |
| Las Vegas MGM | Diamondbacks |
|
Round 4, 12th Pick (1B Anthony Rizzo NYA) |
C
Endy Rodriguez
Pit |
| Week 7 | |
| Las Vegas MGM | Cole's American Giants |
|
SP
Gerrit Cole
NYA RP Devin Williams Mil SS Anthony Volpe NYA C Ivan Herrera StL OF Michael Harris Atl OF Pete Crow-Armstrong ChN OF Sal Frelick Mil |
SP
Sonny Gray
StL C J.T. Realmuto Phi SP Jose Berrios Tor SS Willy Adames Mil 1B Nate Lowe Tex 2B Nico Hoerner ChN OF Christopher Morel ChN |