| Week | Add | Drop |
| Pre-Season |
Round 1: SP Reid Detmers - LAA Round 2: SS Tim Anderson - Mia Round A: OF Jung Hoo Lee - SF | |
| Week 1 |
Round 1: SS Oswaldo Cabrera - NYA Round 2: SP Brady Singer - KC |
Round 2: SS Tim Anderson - Mia |
| Week 2 |
Round 1: 2B Brendan Donovan - StL Round 2: 2B Vaughn Grissom - Bos |
Round 1: OF Daulton Varsho - Tor |
| Week 3 |
Round 1: SS Jose Caballero - TB Round 2: OF Jurickson Profar - SD |
Round 2: RP Tanner Scott - Mia |
| Week 4 |
Round 1: SP Lance Lynn - StL Round 2: OF Daulton Varsho - Tor |
Round 1: SS Trevor Story - Bos Round 2: OF Jurickson Profar - SD |
| Week 5 |
Round 1: C Connor Wong - Bos |
Round 1: C Keibert Ruiz - Was Round 2: SP Hunter Brown - Hou |
| Week 6 |
Round 1: SP Colin Rea - Mil Round 2: 3B J.D. Davis - Oak |
Round 2: SP Lance Lynn - StL Round 2: 1B Joshua Bell - Mia |
| Week 7 |
Round 1: OF Tommy Pham - ChA Round 2: 1B Joshua Bell - Mia |
Round 2: 3B J.D. Davis - Oak |
| 1st Team | 2nd Team |
| Pre-Season | |
| 18 Gamers | The Plantation |
|
Round 3, 10th Pick (2B Brandon Drury LAA) |
OF
Randy Arozarena
TB |
| Pre-Season | |
| 18 Gamers | The Plantation |
|
Round 4, 10th Pick (SS J.P. Crawford Sea) |
SP
Aaron Nola
Phi |
| Pre-Season | |
| 18 Gamers | Las Vegas MGM |
|
Round 1, 2nd Pick (SP Freddy Peralta Mil) Round 6, 2nd Pick (SP Kyle Bradish Bal) |
OF
Kyle Schwarber
Phi |
| Pre-Season | |
| 18 Gamers | Navigators |
|
OF
Evan Carter
Tex Round 2, 2nd Pick (RP Raisel Iglesias Atl) |
2B
Jose Altuve
Hou Round 17, 8th Pick (2B Luis Rengifo LAA) |
| Pre-Season | |
| 18 Gamers | Las Vegas MGM |
|
SP
Grayson Rodriguez
Bal |
C
William Contreras
Mil |
| Pre-Season | |
| 18 Gamers | Brew's Crew |
|
Round 18, 2nd Pick (SP Jacob deGrom Tex) Round 19, 2nd Pick (2B Brendan Rodgers Col) |
Round 4, 3rd Pick (RP Ryan Helsley StL) Round 9, 3rd Pick (2B Luis Arraez SD) |
| Pre-Season | |
| 18 Gamers | Dave's Destroyer's V |
|
SP
Jeffrey Springs
TB |
Round 4, 10th Pick (SS J.P. Crawford Sea) |
| Pre-Season | |
| 18 Gamers | Cole's American Giants |
|
SP
Kyle Harrison
SF |
Round 9, 5th Pick (SP Hunter Brown Hou) |
| Pre-Season | |
| 18 Gamers | Dave's Destroyer's V |
|
SP
Sandy Alcántra
Mia Round 17, 2nd Pick (SP Miles Mikolas StL) |
Round 3, 10th Pick (2B Brandon Drury LAA) |
| Week 1 | |
| 18 Gamers | The Plantation |
|
OF
Anthony Santander
Bal |
3B
Nolan Arenado
StL |