| Week | Add | Drop |
| Pre-Season |
Round 1: SP Jared Jones - Pit Round 2: SP Gavin Williams - Cle |
Round 1: 3B Curtis Mead - TB Round 2: SP Brandon Pfaadt - Ari |
| Week 1 |
Round 1: SP Brandon Pfaadt - Ari Round 2: RP Garrett Whitlock - Bos | |
| Week 2 |
Round 1: SP Max Meyer - Mia Round 2: RP David Robertson - Tex |
Round 2: RP Alex Lange - Det |
| Week 3 |
Round 1: SP MacKenzie Gore - Was Round 2: C Travis d'Arnaud - Atl |
Round 1: SS Trevor Story - Bos Round 2: SP AJ Puk - Mia |
| Week 4 |
Round 1: RP Joel Payamps - Mil Round 2: RP Abner Uribe - Mil |
Round 1: RP David Robertson - Tex Round 2: RP Joel Payamps - Mil |
| Week 5 |
Round 1: OF Pete Crow-Armstrong - ChN Round 2: 2B Josh Rojas - Sea |
Round 1: 2B Whit Merrifield - Phi Round 2: RP Abner Uribe - Mil |
| Week 6 |
Round 1: SP Colin Rea - Mil Round 2: SS Amed Rosario - TB |
Round 1: OF Jarred Kelenic - Atl Round 2: SP Brandon Pfaadt - Ari |
| 1st Team | 2nd Team |
| Pre-Season | |
| Rounding Third | Lehigh Valley Iron Pigs |
|
2B
Marcus Semien
Tex SP Logan Webb SF RP David Bednar Pit Round 5, 9th Pick (SP Kyle Bradish Bal) |
2B
Matt McLain
Cin OF Wyatt Langford Tex |
| Pre-Season | |
| Rounding Third | Santa Fe Fuego |
|
SP
George Kirby
Sea |
Round 3, 5th Pick (SP Merrill Kelly Ari) |
| Pre-Season | |
| Rounding Third | Chattanooga Lookouts |
|
SP
Logan Gilbert
Sea |
Round 8, 8th Pick (SP Michael King SD) |
| Pre-Season | |
| Rounding Third | Lehigh Valley Iron Pigs |
|
SS
C.J. Abrams
Was |
Round 9, 3rd Pick (OF Jarred Kelenic Atl) |
| Week 5 | |
| Rounding Third | Chattanooga Lookouts |
|
SP
Jared Jones
Pit |
RP
Alexis Diaz
Cin |