| Week | Add | Drop |
| Pre-Season |
Round A: SS Sebastian Walcott - Tex |
Round A: 1B Jose Miranda - Min |
| Week 1 |
Round 1: SS Jordan Lawlar - Ari Round 2: RP Alexis Diaz - LAD Round 3: 1B Joshua Bell - Was |
Round 2: OF Nolan Jones - Cle |
| Week 2 |
Round 1: RP AJ Puk - Ari Round 2: OF Zac Veen - Col Round 3: SP Kumar Rocker - Tex |
Round 2: RP David Bednar - Pit Round 2: 3B Brett Baty - NYN Round 3: 1B Joshua Bell - Was |
| Week 3 |
Round 1: 3B Noelvi Marte - Cin Round 3: 2B Edouard Julien - Min |
Round 3: SP Justin Steele - ChN |
| Week 4 |
Round 1: SP Clarke Schmidt - NYA Round 2: 2B Christian Moore - LAA Round 3: SP Tomoyuki Sugano - Bal |
Round 1: 2B Edouard Julien - Min Round 2: SP Will Warren - NYA Round 2: 3B Noelvi Marte - Cin Round 2: SP Kumar Rocker - Tex Round 3: RP AJ Puk - Ari |
| Week 5 |
Round 1: SP Luis Severino - Oak Round 2: SP Clayton Kershaw - LAD Round 3: SP Luke Weaver - NYA |
Round 1: OF Zac Veen - Col Round 3: RP Alexis Diaz - LAD |
| Week 6 |
Round 1: SP Lance McCullers - Hou Round 2: OF Jordan Walker - StL Round 3: 3B Dylan Moore - Sea |
Round 2: SP Clarke Schmidt - NYA Round 3: OF Michael Conforto - LAD |
| Week 7 |
Round 1: 3B Zach Dezenzo - Hou Round 2: 1B Tim Elko - ChA |
Round 1: SP Jared Jones - Pit Round 2: SP Lance McCullers - Hou Round 2: 1B Andrew Vaughn - Mil |
| Week 8 |
Round 1: 1B Jake Burger - Tex Round 3: SP Hayden Birdsong - SF |
Round 1: OF Jordan Walker - StL Round 3: SP Gavin Williams - Cle |
| Week 9 |
Round 1: OF Parker Meadows - Det Round 2: OF Mike Yastrzemski - SF Round 3: SP Jose Berrios - Tor |
Round 1: 3B Zach Dezenzo - Hou Round 2: 1B Tim Elko - ChA Round 3: SP Clayton Kershaw - LAD |
| Week 10 |
Round 1: OF Nick Castellanos - Phi Round 3: 2B Hyeseong Kim - LAD |
Round 1: OF Mike Yastrzemski - SF Round 2: SP Hayden Birdsong - SF |
| Week 11 |
Round 1: SS Ronny Mauricio - NYN Round 3: SP Colin Rea - ChN |
Round 1: 3B Dylan Moore - Sea Round 3: SP Walker Buehler - Bos |
| Week 12 |
Round 1: RP Shelby Miller - Ari Round 2: SP Hayden Birdsong - SF Round 3: SP Emmet Sheehan - LAD |
Round 1: SP Colin Rea - ChN Round 2: SP Luis Severino - Oak Round 3: SP Hayden Birdsong - SF |
| Week 13 |
Round 1: SP Brandon Pfaadt - Ari Round 2: RP Orion Kerkering - Phi |
Round 2: OF Parker Meadows - Det |
| Week 14 |
Round 3: 3B Otto Kemp - Phi |
Round 2: SP Tomoyuki Sugano - Bal |
| 1st Team | 2nd Team |
| Pre-Season | |
| Caught in a run down | Minneapolis Keystones |
|
2B
Matt McLain
Cin |
Round 2, 1st Pick (SP Jackson Jobe Det) |
| Pre-Season | |
| Caught in a run down | Seattle Steelheads |
|
1B
Paul Goldschmidt
NYA |
Round 8, 2nd Pick (RP David Bednar Pit) |
| Pre-Season | |
| Caught in a run down | Santa’s Stars |
|
1B
Vinnie Pasquantino
KC |
Round 5, 6th Pick (SP Carlos Rodon NYA) |
| Pre-Season | |
| Caught in a run down | Seattle Steelheads |
|
RP
Ryan Helsley
StL SP Grayson Rodriguez Bal OF Michael Harris II Atl Round 2, 8th Pick (SP Aaron Nola Phi) |
OF
Wyatt Langford
Tex Round 19, 2nd Pick (SP Will Warren NYA) |
| Pre-Season | |
| Caught in a run down | Seattle Steelheads |
|
3B
Josh Jung
Tex |
Round 6, 2nd Pick (SP Gavin Williams Cle) |
| Week 14 | |
| Caught in a run down | Acuna Machado |
|
SP
Tarik Skubal
Det SP Jackson Jobe Det RP Orion Kerkering Phi 2B Hyeseong Kim LAD |
SP
Zach Eflin
Bal SP George Kirby Sea OF Andy Pages LAD 1B Nick Kurtz Oak |