| Week | Add | Drop |
| Pre-Season |
Round A: SS Sebastian Walcott  |
Round A: 1B Jose Miranda  |
| Week 1 |
Round 1: SS Jordan Lawlar  Round 2: RP Alexis Diaz  Round 3: 1B Joshua Bell  |
Round 2: OF Nolan Jones  |
| Week 2 |
Round 1: RP AJ Puk Round 2: OF Zac Veen  Round 3: SP Kumar Rocker |
Round 2: RP David Bednar  Round 2: 3B Brett Baty  Round 3: 1B Joshua Bell |
| Week 3 |
Round 1: 3B Noelvi Marte  Round 3: 2B Edouard Julien |
Round 3: SP Justin Steele  |
| Week 4 |
Round 1: SP Clarke Schmidt Round 2: 2B Christian Moore  Round 3: SP Tomoyuki Sugano  |
Round 1: 2B Edouard Julien Round 2: SP Will Warren Round 2: 3B Noelvi Marte Round 2: SP Kumar Rocker Round 3: RP AJ Puk |
| Week 5 |
Round 1: SP Luis Severino  Round 2: SP Clayton Kershaw  Round 3: SP Luke Weaver |
Round 1: OF Zac Veen Round 3: RP Alexis Diaz |
| Week 6 |
Round 1: SP Lance McCullers  Round 2: OF Jordan Walker  Round 3: 3B Dylan Moore |
Round 2: SP Clarke Schmidt Round 3: OF Michael Conforto |
| Week 7 |
Round 1: 3B Zach Dezenzo Round 2: 1B Tim Elko  |
Round 1: SP Jared Jones  Round 2: SP Lance McCullers Round 2: 1B Andrew Vaughn  |
| Week 8 |
Round 1: 1B Jake Burger Round 3: SP Hayden Birdsong  |
Round 1: OF Jordan Walker Round 3: SP Gavin Williams |
| Week 9 |
Round 1: OF Parker Meadows  Round 2: OF Mike Yastrzemski  Round 3: SP Jose Berrios  |
Round 1: 3B Zach Dezenzo Round 2: 1B Tim Elko Round 3: SP Clayton Kershaw |
| Week 10 |
Round 1: OF Nick Castellanos  Round 3: 2B Hyeseong Kim |
Round 1: OF Mike Yastrzemski Round 2: SP Hayden Birdsong |
| Week 11 |
Round 1: SS Ronny Mauricio Round 3: SP Colin Rea |
Round 1: 3B Dylan Moore Round 3: SP Walker Buehler |
| Week 12 |
Round 1: RP Shelby Miller Round 2: SP Hayden Birdsong Round 3: SP Emmet Sheehan |
Round 1: SP Colin Rea Round 2: SP Luis Severino Round 3: SP Hayden Birdsong |
| Week 13 |
Round 1: SP Brandon Pfaadt Round 2: RP Orion Kerkering |
Round 2: OF Parker Meadows |
| Week 14 |
Round 3: 3B Otto Kemp |
Round 2: SP Tomoyuki Sugano |
| Week 15 |
Round 1: SP Grant Holmes |
Round 1: 3B Otto Kemp |
| Week 16 |
Round 3: SP Chris Flexen |
Round 3: 1B Jake Burger |
| Week 17 |
Round 2: SP Luke Weaver | |
| Week 18 |
Round 1: OF Colby Thomas Round 2: RP Daniel Palencia Round 3: SP Brad Lord |
Round 3: SP Chris Flexen |
| Week 19 |
Round 1: SS Jett Williams | |
| Week 22 |
Round 2: OF Lazaro Montes  |
Round 2: RP Shelby Miller Round 2: 2B Christian Moore |
| Week 24 |
Round 1: RP Devin Williams Round 3: SP Kodai Senga |
Round 1: SP Brad Lord Round 2: OF Nick Castellanos Round 3: C Logan O'Hoppe |
| 1st Team | 2nd Team |
| Pre-Season | |
| Caught in a run down | Minneapolis Keystones |
|
2B
Matt McLain
|
Round 2, 1st Pick (SP Jackson Jobe ) |
| Pre-Season | |
| Caught in a run down | Southie Trash Pandas |
|
1B
Paul Goldschmidt
|
Round 8, 2nd Pick (RP David Bednar ) |
| Pre-Season | |
| Caught in a run down | Santa’s Stars |
|
1B
Vinnie Pasquantino
|
Round 5, 6th Pick (SP Carlos Rodon ) |
| Pre-Season | |
| Caught in a run down | Southie Trash Pandas |
|
RP
Ryan Helsley
SP Grayson Rodriguez OF Michael Harris II Round 2, 8th Pick (SP Aaron Nola ) |
OF
Wyatt Langford
Round 19, 2nd Pick (SP Will Warren ) |
| Pre-Season | |
| Caught in a run down | Southie Trash Pandas |
|
3B
Josh Jung
|
Round 6, 2nd Pick (SP Gavin Williams ) |
| Week 14 | |
| Caught in a run down | Acuna Machado |
|
SP
Tarik Skubal
SP Jackson Jobe RP Orion Kerkering 2B Hyeseong Kim |
SP
Zach Eflin
SP George Kirby OF Andy Pages 1B Nick Kurtz |
| Week 18 | |
| Caught in a run down | Southie Trash Pandas |
|
SS
Corey Seager
2B Ozzie Albies |
|