| Week | Add | Drop |
| Pre-Season |
Round 1: SP Ranger Suarez - Phi Round 2: OF Dominic Canzone - Sea Round A: C Ethan Salas - SD Round B: SP John Means - Bal |
Round A: 1B Alex Kirilloff - Min Round B: SP Rich Hill - F/A |
| Week 1 |
Round 1: SP Jordan Hicks - SF Round 2: 3B Curtis Mead - TB | |
| Week 2 |
Round 1: SP Logan Allen - Cle Round 2: OF Connor Joe - Pit | |
| Week 3 |
Round 1: SS Blaze Alexander - Ari Round 2: C Ivan Herrera - StL |
Round 1: SS Zach Neto - LAA Round 2: C Freddy Fermin - KC |
| Week 4 |
Round 1: RP Kirby Yates - Tex |
Round 1: OF Dominic Canzone - Sea |
| Week 5 |
Round 1: OF Wilyer Abreu - Bos Round 2: SP Gavin Stone - LAD |
Round 1: SP Miles Mikolas - StL Round 2: 3B Curtis Mead - TB |
| Week 6 |
Round 1: 3B Tyler Black - Mil Round 2: SP John Means - Bal |
Round 1: C Ivan Herrera - StL Round 2: SP Yariel Rodriguez - Tor |
| 1st Team | 2nd Team |
| Pre-Season | |
| Glendale Desert Dogs | Dodgers |
|
C
Yan Gomes
ChN |
Round 1, 8th Pick (SP Chris Sale Atl) Round 5, 8th Pick (1B Anthony Rizzo NYA) |
| Pre-Season | |
| Glendale Desert Dogs | Basket Case |
|
2B
Luis Garcia
Was |
Round 4, 11th Pick (SP Kyle Harrison SF) |
| Pre-Season | |
| Glendale Desert Dogs | Bleacher Bums |
|
OF
Michael Harris
Atl |
Round 2, 2nd Pick (SP Carlos Rodon NYA) Round 14, 2nd Pick (SP Charlie Morton Atl) |
| Pre-Season | |
| Glendale Desert Dogs | Giants |
|
Round 2, 2nd Pick (SP Carlos Rodon NYA) Round 1, 8th Pick (SP Chris Sale Atl) Round 4, 11th Pick (SP Kyle Harrison SF) |
OF
Mike Trout
LAA Round 18, 10th Pick (C Freddy Fermin KC) Round 19, 10th Pick (SP Tanner Houck Bos) |
| Pre-Season | |
| Glendale Desert Dogs | Basket Case |
|
Round 1, 5th Pick (RP Jordan Romano Tor) Round 3, 5th Pick (SP Aaron Nola Phi) Round 7, 5th Pick (OF Chas McCormick Hou) |
1B
Paul Goldschmidt
StL C J.T. Realmuto Phi SP Joe Musgrove SD 2B Jonathan India Cin |
| Pre-Season | |
| Glendale Desert Dogs | No Clue |
|
Round 5, 5th Pick (2B Jonathan India Cin) |
OF
Byron Buxton
Min |
| Pre-Season | |
| Glendale Desert Dogs | NYSE: BABA |
|
Round 2, 5th Pick (RP Raisel Iglesias Atl) Round 4, 5th Pick (RP Adbert Alzolay ChN) |
OF
Eloy Jimenez
ChA SP Luis Castillo Sea |
| Week 4 | |
| Glendale Desert Dogs | Basket Case |
|
1B
Anthony Rizzo
NYA OF Eloy Jimenez ChA SP Ranger Suarez Phi |
SP
Max Meyer
Mia OF Chase DeLauter Cle OF Joey Loperfido Hou SP Yariel Rodriguez Tor |