| Week | Add | Drop |
| Pre-Season |
Round 1: OF Mitch Haniger - Sea Round 2: OF Jose Siri - TB Round A: SP Ryan Pepiot - TB Round B: SS Marcelo Mayer - Bos Round C: SS Jackson Merrill - SD |
Round A: C Travis d'Arnaud - Atl Round B: SP Yusei Kikuchi - Tor |
| Week 1 |
Round 1: C Connor Wong - Bos Round 2: SP Sean Manaea - NYN | |
| Week 2 |
Round 1: RP James McArthur - KC Round 2: SS David Hamilton - Bos | |
| Week 3 |
Round 1: 3B Anthony Rendon - LAA Round 2: C Joey Bart - Pit |
Round 2: C Connor Wong - Bos |
| Week 4 |
Round 1: OF Jesse Winker - Was Round 2: SP Mike Lorenzen - Tex |
Round 1: RP Will Smith - KC Round 2: SS David Hamilton - Bos |
| Week 5 |
Round 1: SP Bryce Elder - Atl Round 2: 3B Jose Miranda - Min |
Round 1: OF Jose Siri - TB Round 2: 3B Anthony Rendon - LAA |
| Week 6 |
Round 1: RP Trevor Megill - Mil Round 2: OF Bryan De La Cruz - Mia |
Round 1: RP Michael Kopech - ChA Round 2: 1B Kris Bryant - Col |
| Week 7 |
Round 1: C Ivan Herrera - StL Round 2: SS Paul DeJong - ChA |
Round 1: 3B Yoan Moncada - ChA Round 2: SP Bryce Elder - Atl |
| 1st Team | 2nd Team |
| Pre-Season | |
| Fort Wayne TinCaps | Bowling Green Hot Rods |
|
Round 10, 10th Pick (SP Gavin Stone LAD) |
SS
Jordan Lawlar
Ari |
| Pre-Season | |
| Fort Wayne TinCaps | Ft Myers Bull Sharks |
|
1B
Josh Naylor
Cle |
Round 4, 7th Pick (SS C.J. Abrams Was) |
| Pre-Season | |
| Fort Wayne TinCaps | Ft Myers Bull Sharks |
|
Round 2, 10th Pick (RP Adbert Alzolay ChN) Round 4, 10th Pick (SP Jose Berrios Tor) |
SS
Junior Caminero
TB |
| Week 7 | |
| Fort Wayne TinCaps | Kane County Cougars |
|
SS
Trea Turner
Phi |
SP
Aaron Nola
Phi SS Bo Bichette Tor |