| Week | Add | Drop |
| Pre-Season |
Round 1: SP Bailey Ober  Round 2: SP Seth Lugo  | |
| Week 1 |
Round 1: 1B Carlos Santana  |
Round 1: SP Seth Lugo |
| Week 2 |
Round 3: 1B Dom Smith  |
Round 3: 1B Carlos Santana |
| Week 3 |
Round 2: 2B Ildemaro Vargas |
Round 2: C Carlos Narvaez  |
| Week 4 |
Round 1: SP Andre Pallante  |
Round 1: OF Cedric Mullins II  |
| Week 6 |
Round 1: OF Joey Wiemer  |
Round 1: OF Mike Yastrzemski |
| Week 7 |
Round 1: SP Peter Lambert  |
Round 1: 2B Tommy Edman  |
| Week 9 |
Round 1: C Agustin Ramirez  | |
| Week 10 |
Round 2: SP Jeffrey Springs  |
Round 2: SP Luis Severino |
| Week 11 |
Round 1: SP Hurston Waldrep Round 2: OF Lars Nootbaar |
Round 1: SP Brayan Bello Round 2: OF Lawrence Butler |
| Week 14 |
Round 1: SP Anthony Kay  |
Round 1: SS Tommy Troy |
| 1st Team | 2nd Team |
| Pre-Season | |
| Cardinals | Swing and Missles 22 |
Round 2, 7th Pick (SP Trevor Rogers  ) |
OF
Dylan Crews
2B Travis Bazzana  |
| Pre-Season | |
| Cardinals | Seventh Inning Stretch |
|
Round 1, 7th Pick (C Carter Jensen ) Round 5, 7th Pick (OF Carson Benge  ) |
2B
Jackson Holliday
Round 3, 12th Pick (SP Joe Ryan )Round 10, 12th Pick (OF Cedric Mullins II ) |
| Pre-Season | |
| Cardinals | Jac Attack |
2B
Brice Turang
 |
Round 2, 12th Pick (OF Lawrence Butler ) |
| Pre-Season | |
| Cardinals | Thirty win special 22 |
Round 6, 7th Pick (SS Dansby Swanson  ) |
OF
Walker Jenkins
|
| Pre-Season | |
| Cardinals | Lexington Legends |
OF
George Springer
 |
C
Adley Rutschman
|
| Week 9 | |
| Cardinals | Swing and Missles 22 |
|
SP
Shane McClanahan
C Adley Rutschman |
OF
Roman Anthony
|
| Week 14 | |
| Cardinals | Thirty win special 22 |
|
C
Salvador Perez
SP Dustin May SP Joe Ryan OF Lars Nootbaar |
OF
Oneil Cruz
 OF Junior Perez C Rafael Flores SS Tommy Troy |