| Week | Add | Drop |
| Pre-Season |
Round 1: SP Jeffrey Springs - Oak Round 2: SP Richard Fitts - Bos Round 3: SP José Soriano - LAA Round A: RP Felix Bautista - Bal Round B: SP Eury Perez - Mia Round C: RP Jeff Hoffman - Tor Round D: OF Zac Veen - Col |
Round 1: SP Ryan Weathers - Mia Round 2: OF Zac Veen - Col |
| Week 1 |
Round 1: 2B Otto Lopez - Mia Round 2: OF Alek Thomas - Ari Round 3: OF Tirso Ornelas - SD |
Round 2: 3B Zach Dezenzo - Hou |
| Week 2 |
Round 1: SS Trey Sweeney - Det Round 2: OF Trent Grisham - NYA Round 3: 1B Matt Mervis - Mia |
Round 1: SS David Hamilton - Bos Round 2: OF Tirso Ornelas - SD Round 3: SP Grant Holmes - Atl |
| Week 3 |
Round 1: SP Logan Allen - Cle Round 2: SP Edward Cabrera - Mia Round 3: OF Kyle Stowers - Mia |
Round 1: OF Lourdes Gurriel - Ari Round 2: SP Logan Allen - Cle Round 3: 1B Jose Miranda - Min |
| Week 4 |
Round 1: SS Gabriel Arias - Cle Round 2: 2B Enmanuel Valdez - Pit Round 3: C Agustin Ramirez - Mia |
Round 1: OF Alek Thomas - Ari Round 2: SS Trey Sweeney - Det Round 3: OF Kyle Stowers - Mia |
| Week 5 |
Round 1: 1B Eric Wagaman - Mia Round 2: C Joey Bart - Pit Round 3: OF Andy Pages - LAD |
Round 1: C Joey Bart - Pit Round 2: 2B Enmanuel Valdez - Pit Round 3: SP Richard Fitts - Bos |
| Week 6 |
Round 1: 3B Miguel Vargas - ChA Round 2: SP Gunnar Hoglund - Oak Round 3: 1B Colt Keith - Det |
Round 1: SP Edward Cabrera - Mia Round 2: SP Eduardo Rodriguez - Ari Round 3: 1B Eric Wagaman - Mia |
| Week 7 |
Round 1: SP Ryan Weathers - Mia Round 2: SP Colin Rea - ChN Round 3: SP Grant Holmes - Atl |
Round 1: 1B Matt Mervis - Mia Round 2: C Joey Bart - Pit Round 3: 3B Miguel Vargas - ChA |
| Week 8 |
Round 1: 2B Brooks Lee - Min Round 2: 3B Miguel Vargas - ChA Round 3: OF Will Benson - Cin |
Round 1: OF Max Kepler - Phi Round 2: 3B Caleb Durbin - Mil Round 2: SP Grant Holmes - Atl Round 3: SS Gabriel Arias - Cle |
| Week 9 |
Round 1: SP Logan Henderson - Mil Round 2: SS Ronny Mauricio - NYN Round 3: OF Parker Meadows - Det |
Round 2: SP Gunnar Hoglund - Oak Round 3: 1B Ryan Mountcastle - Bal |
| Week 10 |
Round 1: RP Daniel Palencia - ChN Round 2: SP Lance McCullers - Hou Round 3: 3B Ernie Clement - Tor |
Round 1: SP Colin Rea - ChN Round 2: SP Jared Jones - Pit Round 3: SP Jeffrey Springs - Oak |
| Week 11 |
Round 1: C Kyle Teel - ChA Round 2: 3B Nick Loftin - KC Round 3: OF Jo Adell - LAA |
Round 1: 3B Ernie Clement - Tor Round 2: OF Will Benson - Cin Round 3: 3B Nick Loftin - KC |
| Week 12 |
Round 1: OF Giancarlo Stanton - NYA Round 2: SP Lucas Giolito - Bos Round 3: OF Wenceel Perez - Det |
Round 1: C Kyle Teel - ChA Round 2: 2B Brooks Lee - Min Round 2: 2B Bryson Stott - Phi |
| Week 13 |
Round 1: 1B Michael Toglia - Col Round 2: SP Didier Fuentes - Atl Round 3: RP Tanner Scott - LAD |
Round 1: SP Ryan Weathers - Mia Round 2: SP Walker Buehler - Bos Round 3: OF Giancarlo Stanton - NYA |
| Week 14 |
Round 1: SP Jacob Lopez - Oak Round 2: SP Edward Cabrera - Mia Round 3: SP Jack Leiter - Tex |
Round 2: SP Logan Henderson - Mil Round 2: SP José Soriano - LAA Round 2: SP Didier Fuentes - Atl Round 3: OF Austin Hays - Cin |
| Week 15 |
Round 2: SP Nick Martinez - Cin |
Round 2: RP Tanner Scott - LAD |
| 1st Team | 2nd Team |
| Pre-Season | |
| Yankoneout | Fredericksburg Nationals |
|
OF
Cody Bellinger
NYA |
C
Adley Rutschman
Bal |
| Pre-Season | |
| Yankoneout | Rocket City Trash Pandas |
|
Round 9, 8th Pick (SP Taj Bradley TB) |
OF
Pete Crow-Armstrong
ChN |
| Pre-Season | |
| Yankoneout | Boognish Rising |
|
Round 1, 8th Pick (SP Shane McClanahan TB) |
1B
Spencer Torkelson
Det 2B Matt McLain Cin |
| Pre-Season | |
| Yankoneout | The Shogun of Harlem |
|
OF
Lawrence Butler
Oak OF Wyatt Langford Tex |
SP
Max Fried
NYA Round 1, 7th Pick (2B Kristian Campbell Bos) Round 5, 7th Pick (SP Robbie Ray SF) |
| Pre-Season | |
| Yankoneout | Pawtucket Red Sox |
|
SP
Max Fried
NYA |
1B
Paul Goldschmidt
NYA |
| Pre-Season | |
| Yankoneout | Rocket City Trash Pandas |
|
2B
Matt McLain
Cin |
3B
Jordan Westburg
Bal |
| Pre-Season | |
| Yankoneout | Boognish Rising |
|
Round 1, 7th Pick (2B Kristian Campbell Bos) |
OF
Jordan Walker
StL RP Mason Miller Oak |
| Pre-Season | |
| Yankoneout | Pawtucket Red Sox |
|
SP
Chris Sale
Atl SP Garrett Crochet Bos |
Round 5, 10th Pick (SP Nick Lodolo Cin) Round 6, 10th Pick (SP Walker Buehler Bos) |
| Pre-Season | |
| Yankoneout | Al Davis Rastafarians |
|
RP
Edwin Diaz
NYN Round 7, 8th Pick (OF Jorge Soler LAA) |
OF
Cody Bellinger
NYA |
| Pre-Season | |
| Yankoneout | Rocket City Trash Pandas |
|
3B
Royce Lewis
Min Round 3, 8th Pick (1B Nick Kurtz Oak) |
C
J.T. Realmuto
Phi 2B Jazz Chisholm Jr. NYA |
| Pre-Season | |
| Yankoneout | Monroe Monarchs |
|
OF
Byron Buxton
Min 2B Brandon Lowe TB |
RP
Jordan Romano
Phi Round 9, 2nd Pick (1B Ryan Mountcastle Bal) |
| Week 3 | |
| Yankoneout | The Shogun of Harlem |
|
2B
Otto Lopez
Mia |
OF
Max Kepler
Phi |
| Week 6 | |
| Yankoneout | Hillsboro Hops |
|
RP
Ryan Helsley
StL |
SP
Andrew Abbott
Cin |
| Week 8 | |
| Yankoneout | Rocket City Trash Pandas |
|
2B
Jazz Chisholm Jr.
NYA 3B Jordan Westburg Bal OF Andy Pages LAD |
2B
Matt McLain
Cin OF Spencer Steer Cin 3B Caleb Durbin Mil |
| Week 11 | |
| Yankoneout | Fredericksburg Nationals |
|
SS
Bobby Witt Jr.
KC OF Colton Cowser Bal 2B Matt McLain Cin |
OF
Cody Bellinger
NYA SP Spencer Strider Atl 2B Jackson Holliday Bal SS Jacob Wilson Oak |
| Week 13 | |
| Yankoneout | Fredericksburg Nationals |
|
RP
Jeff Hoffman
Tor C Adley Rutschman Bal RP Mason Miller Oak |
SP
Sandy Alcantara
Mia C Carlos Narvaez Bos SP Yoshinobu Yamamoto LAD |