| Week | Add | Drop |
| Pre-Season |
Round 1: SP Jared Jones - Pit Round 2: SP Tyler Wells - Bal |
Round 1: SP Lucas Giolito - Bos |
| Week 1 |
Round 1: SP Erick Fedde - StL | |
| Week 4 |
Round 1: C Connor Wong - Bos Round 2: SP Joe Boyle - Oak |
Round 1: SP Shane Bieber - Cle Round 2: SP Shane Bieber - Cle |
| Week 6 |
Round 1: SP Luis Gil - NYA |
Round 1: SP J.P. France - Hou |
| Week 7 |
Round 1: SP Patrick Sandoval - LAA |
Round 1: SP Joe Boyle - Oak |
| Week 10 |
Round 1: 1B Ryan O'Hearn - Bal Round 2: SP Ryan Weathers - Mia |
Round 1: OF James Outman - LAD Round 2: SP Tyler Wells - Bal |
| Week 14 |
Round 1: SP Yusei Kikuchi - Hou Round 2: 2B Rob Refsnyder - Bos |
Round 1: SP Patrick Sandoval - LAA Round 2: 3B Ezequiel Duran - Tex |
| Week 18 |
Round 1: SP Cal Quantrill - Col |
Round 1: SP Lance Lynn - StL |
| Week 19 |
Round 1: SS Jose Iglesias - NYN |
Round 1: C Keibert Ruiz - Was |
| 1st Team | 2nd Team |