| Week | Add | Drop |
| Pre-Season |
Round 1: 1B Rowdy Tellez - Pit Round 2: SP Trevor Rogers - Mia Round A: OF Hunter Goodman - Col |
Round A: SP Drey Jameson - Ari |
| Week 1 |
Round 2: SP Emerson Hancock - Sea | |
| Week 2 |
Round 1: OF Heston Kjerstad - Bal Round 2: SS Tyler Freeman - Cle | |
| Week 3 |
Round 1: SP Reynaldo Lopez - Atl Round 2: 3B Josh Smith - Tex | |
| Week 4 |
Round 1: RP Kirby Yates - Tex | |
| Week 5 |
Round 1: OF Hunter Goodman - Col Round 2: OF Blake Perkins - Mil |
Round 1: RP Jose Leclerc - Tex Round 2: OF Aaron Hicks - LAA |
| Week 6 |
Round 1: SP Trevor Rogers - Mia Round 2: OF Parker Meadows - Det Round 2: RP Griffin Jax - Min | |
| Week 7 |
Round 1: 2B Jace Jung - Det |
| 1st Team | 2nd Team |
| Pre-Season | |
| Albuquerque Isotopes | Fightins |
|
Round 7, 6th Pick (SP Sonny Gray StL) |
OF
Dylan Crews
Was |
| Pre-Season | |
| Albuquerque Isotopes | The Shogun of Harlem |
|
Round 1, 6th Pick (OF Tyler O'Neill Bos) Round 3, 6th Pick (SP Tanner Bibee Cle) |
SP
Gerrit Cole
NYA |
| Pre-Season | |
| Albuquerque Isotopes | Chaos Creators |
|
SP
Gerrit Cole
NYA SS Corey Seager Tex SP Tarik Skubal Det |
OF
Luis Robert
ChA OF Corbin Carroll Ari 2B Colt Keith Det |
| Pre-Season | |
| Albuquerque Isotopes | The Shogun of Harlem |
|
Round 8, 6th Pick (OF Matt Wallner Min) |
SS
Ezequiel Tovar
Col |
| Pre-Season | |
| Albuquerque Isotopes | The Shogun of Harlem |
|
Round 4, 6th Pick (2B Edouard Julien Min) |
SP
Pablo Lopez
Min Round 19, 12th Pick (OF Nelson Velazquez KC) |
| Week 6 | |
| Albuquerque Isotopes | Bottom of the pack 15 |
|
RP
Jhoan Duran
Min |
SP
Mitch Keller
Pit RP Devin Williams Mil |