| Week | Add | Drop |
| Pre-Season |
Round 1: DH Mitch Garver - Sea Round 2: SP Kenta Maeda - Det Round A: SP Nick Lodolo - Cin Round B: SP Jacob deGrom - Tex |
Round 1: 1B C.J. Cron - F/A Round A: C Travis d'Arnaud - Atl Round B: C Elias Diaz - Col |
| Week 1 |
Round 2: SP Paul Blackburn - Oak | |
| Week 2 |
Round 1: 2B Brendan Donovan - StL Round 2: OF Micahel Taylor - Pit |
Round 2: SP Tylor Megill - NYN |
| Week 3 |
Round 1: SP Reynaldo Lopez - Atl Round 2: 3B Oliver Dunn - Mil |
Round 1: 3B Yoan Moncada - ChA Round 2: OF Max Kepler - Min |
| Week 4 |
Round 1: SP Lance Lynn - StL |
Round 1: C Alejandro Kirk - Tor |
| Week 5 |
Round 1: OF Wilyer Abreu - Bos Round 2: OF Jo Adell - LAA |
Round 1: SP Kenta Maeda - Det Round 2: OF Mickey Moniak - LAA |
| Week 6 |
Round 1: SP Trevor Williams - Was Round 2: 1B David Fry - Cle |
Round 1: OF Micahel Taylor - Pit Round 2: C Austin Wells - NYA |
| Week 7 |
Round 1: 3B Brett Harris - Oak Round 2: 2B Jace Jung - Det |
Round 1: 3B Oliver Dunn - Mil Round 2: DH Mitch Garver - Sea Round 2: SP Lance Lynn - StL |
| 1st Team | 2nd Team |
| Pre-Season | |
| Charleston Dirty Birds | Sons of Pitches |
|
SP
Zach Wheeler
Phi 2B Marcus Semien Tex Round 1, 8th Pick (OF Jorge Soler SF) Round 2, 8th Pick (1B Anthony Rizzo NYA) |
1B
Bryce Harper
Phi Round 13, 9th Pick (C Austin Wells NYA) Round 19, 9th Pick (SP Yusei Kikuchi Tor) |
| Pre-Season | |
| Charleston Dirty Birds | Horseheads Buffalos |
|
3B
Gunnar Henderson
Bal |
3B
Manny Machado
SD SP Zach Wheeler Phi 2B Marcus Semien Tex SP Luis Castillo Sea SP Pablo Lopez Min |
| Pre-Season | |
| Charleston Dirty Birds | Brooklyn Cyclones III |
|
2B
Nolan Gorman
StL |
Round 7, 2nd Pick (1B Jeimer Candelario Cin) |