| Week | Add | Drop |
| Pre-Season |
Round 1: 1B Joshua Bell - Mia Round 2: RP Abner Uribe - Mil | |
| Week 1 |
Round 1: RP Michael Kopech - ChA Round 2: RP Ronel Blanco - Hou |
Round 2: SS Marco Luciano - SF |
| Week 2 |
Round 1: RP David Robertson - Tex Round 2: SS Jose Caballero - TB |
Round 1: SP Shane Bieber - Cle Round 2: RP Yimi Garcia - Tor |
| Week 3 |
Round 1: SP AJ Smith-Shawver - Atl Round 2: 2B Brendan Rodgers - Col | |
| Week 4 |
Round 1: OF Andy Pages - LAD Round 2: SP Yariel Rodriguez - Tor |
Round 1: RP David Robertson - Tex Round 2: SP AJ Smith-Shawver - Atl |
| Week 5 |
Round 1: SP Yu Darvish - SD Round 2: RP Yennier Cano - Bal |
Round 1: 2B Brendan Rodgers - Col Round 2: RP Abner Uribe - Mil |
| Week 6 |
Round 1: RP Jhoan Duran - Min Round 2: RP Peter Fairbanks - TB |
Round 1: RP Yennier Cano - Bal Round 2: SP Yariel Rodriguez - Tor |
| Week 7 |
Round 1: C Keibert Ruiz - Was Round 2: RP Yennier Cano - Bal |
Round 1: 1B Joshua Bell - Mia Round 2: 3B Curtis Mead - TB Round 2: RP Michael Kopech - ChA |
| 1st Team | 2nd Team |
| Pre-Season | |
| Horseheads Buffalos | Charleston Dirty Birds |
|
3B
Manny Machado
SD SP Zach Wheeler Phi 2B Marcus Semien Tex SP Luis Castillo Sea SP Pablo Lopez Min |
3B
Gunnar Henderson
Bal |