| Week | Add | Drop |
| Week 1 |
Round 1: 2B Cavan Biggio - Atl | |
| Week 2 |
Round 2: C Reese McGuire - Bos |
Round 2: 2B Cavan Biggio - Atl |
| Week 3 |
Round 1: SP Bailey Ober - Min Round 2: SP Braxton Garrett - Mia | |
| Week 4 |
Round 1: C Danny Jansen - Bos Round 2: SP Jameson Taillon - ChN |
Round 1: C Reese McGuire - Bos Round 2: C Tyler Stephenson - Cin |
| Week 5 |
Round 1: C Tyler Stephenson - Cin Round 2: 3B Patrick Wisdom - ChN |
Round 1: DH Mitch Garver - Sea Round 2: SP Braxton Garrett - Mia |
| Week 6 |
Round 2: 1B Nolan Schanuel - LAA |
Round 2: 1B Joshua Bell - Ari |
| Week 7 |
Round 2: 1B Joshua Bell - Ari |
Round 2: 1B Nolan Schanuel - LAA |
| Week 8 |
Round 1: OF Lane Thomas - Cle Round 2: OF Tommy Pham - KC |
Round 1: OF Masataka Yoshida - Bos Round 2: OF Cedric Mullins - Bal |
| Week 9 |
Round 1: RP José Soriano - LAA Round 1: RP José Soriano - LAA Round 2: 3B Ke'Bryan Hayes - Pit |
Round 2: 1B Joshua Bell - Ari |
| Week 10 |
Round 1: SP Braxton Garrett - Mia Round 2: SP Ryan Weathers - Mia |
Round 1: 3B Patrick Wisdom - ChN Round 2: SS Oswaldo Cabrera - NYA |
| Week 11 |
Round 1: SP Jake Irvin - Was Round 2: SP Blake Snell - SF |
Round 2: C Tyler Stephenson - Cin |
| Week 12 |
Round 1: SP Cal Quantrill - Col Round 2: 3B Joey Ortiz - Mil |
Round 1: SP Dane Dunning - Tex Round 2: OF Tommy Pham - KC |
| Week 13 |
Round 1: 2B Zack Gelof - Oak Round 2: 2B Xander Bogaerts - SD |
Round 1: SP Braxton Garrett - Mia Round 2: SP Ryan Weathers - Mia |
| Week 14 |
Round 2: SP Josiah Gray - Was |
Round 2: 3B Ke'Bryan Hayes - Pit |
| Week 15 |
Round 1: 3B Daniel Schneemann - Cle Round 2: C Elias Diaz - SD |
Round 1: SP Josiah Gray - Was Round 2: C Danny Jansen - Bos |
| Week 16 |
Round 2: C Tyler Stephenson - Cin |
Round 2: C Elias Diaz - SD |
| Week 17 |
Round 2: 3B Daniel Schneemann - Cle | |
| Week 18 |
Round 1: SP River Ryan - LAD |
Round 1: SP Cal Quantrill - Col |
| Week 19 |
Round 1: SP Paul Blackburn - NYN Round 2: 3B Brooks Baldwin - ChA |
Round 1: SP Bobby Miller - LAD Round 2: 3B Joey Ortiz - Mil |
| Week 20 |
Round 1: SP Eduardo Rodriguez - Ari Round 2: OF Jerar Encarnación - SF |
Round 1: SP Nestor Cortes Jr. - NYA Round 2: SP River Ryan - LAD |
| Week 22 |
Round 1: 1B Moises Ballesteros - ChN Round 2: SS JJ Wetherholt - StL |
Round 1: OF Jerar Encarnación - SF Round 2: 3B Brooks Baldwin - ChA Round 2: SP Jordan Montgomery - Ari |
| 1st Team | 2nd Team |
| Pre-Season | |
| AMS Power | Temple of Doom 25 |
|
SP
Tyler Wells
Bal |
Round 6, 12th Pick (OF Brandon Nimmo NYN) |
| Week 9 | |
| AMS Power | Poker in the Rear |
|
SP
Max Meyer
Mia SS Jackson Merrill SD SP Bryce Miller Sea |
OF
Teoscar Hernández
LAD SS Oswaldo Cabrera NYA |
| Week 10 | |
| AMS Power | Pittsburgh Crawfords |
|
SP
Triston McKenzie
Cle SP Framber Valdez Hou |
2B
Bryson Stott
Phi |
| Week 14 | |
| AMS Power | Fly the W |
|
2B
Xander Bogaerts
SD OF George Springer Tor |
SP
Luis Severino
NYN OF Eloy Jimenez ChA |