| Week | Add | Drop |
| Pre-Season |
Round 1: SP Jack Flaherty - Det Round 2: RP Robert Suarez - SD Round A: 1B Michael Busch - ChN Round B: SP Shane Baz - TB Round C: SS Jackson Merrill - SD |
Round A: C Patrick Bailey - SF Round B: SP Clarke Schmidt - NYA Round C: RP Ryan Pressly - Hou |
| Week 1 |
Round 1: OF Connor Joe - Pit Round 2: OF Nick Martini - Cin | |
| Week 2 |
Round 1: SP Reese Olson - Det Round 2: OF JJ Bleday - Oak |
Round 2: OF Austin Hays - Bal |
| Week 3 |
Round 1: SS Jose Caballero - TB Round 2: OF Jesse Winker - Was |
Round 1: SS Javier Baez - Det Round 2: OF JJ Bleday - Oak |
| Week 4 |
Round 1: 1B Ryan O'Hearn - Bal Round 2: OF Bryan De La Cruz - Mia |
Round 1: 1B Ty France - Sea Round 2: OF Jose Siri - TB |
| Week 5 |
Round 1: SP Casey Mize - Det Round 2: 3B Nick Senzel - Was |
Round 1: OF Nick Martini - Cin Round 2: 3B Jared Triolo - Pit |
| Week 6 |
Round 1: OF Wenceel Perez - Det Round 2: SP Shane Baz - TB |
Round 1: 2B Brandon Drury - LAA Round 2: SP Aaron Civale - TB |
| Week 7 |
Round 1: OF Mike Tauchman - ChN Round 2: 1B David Fry - Cle |
Round 1: 3B D.J. LeMahieu - NYA Round 2: OF Jesse Winker - Was |
| Week 8 |
Round 1: 3B Mark Vientos - NYN Round 2: 1B Jonathan Singleton - Hou |
Round 1: OF TJ Friedl - Cin Round 2: OF Mike Tauchman - ChN |
| Week 9 |
Round 1: 3B Miguel Andújar - Oak Round 1: 3B Miguel Andújar - Oak |
Round 1: 3B Nick Senzel - Was Round 1: 3B Nick Senzel - Was |
| 1st Team | 2nd Team |