| Week | Add | Drop |
| Pre-Season |
Round 1: SP Joe Boyle - Oak Round 2: C Gary Sanchez - Mil Round A: SP Brandon Pfaadt - Ari Round B: SP Trevor Bauer - LAD |
Round A: C Freddy Fermin - KC Round B: C Tyler Stephenson - Cin |
| Week 1 |
Round 2: RP Garrett Whitlock - Bos | |
| Week 2 |
Round 1: SP Kyle Gibson - StL Round 2: OF Micahel Taylor - Pit | |
| Week 3 |
Round 1: SP Cody Bradford - Tex | |
| Week 4 |
Round 1: RP Kirby Yates - Tex | |
| Week 5 |
Round 1: OF Pete Crow-Armstrong - ChN Round 2: 1B LaMonte Wade Jr - SF |
Round 1: RP Will Smith - KC Round 2: OF Micahel Taylor - Pit Round 2: SP Joe Boyle - Oak |
| Week 6 |
Round 1: 2B Willi Castro - Min Round 2: C Connor Wong - Bos |
Round 2: C Alejandro Kirk - Tor |
| Week 7 |
Round 1: SP Chris Paddack - Min Round 2: 2B Nick Gonzales - Pit |
Round 1: 1B LaMonte Wade Jr - SF Round 2: SP Jordan Wicks - ChN |
| 1st Team | 2nd Team |
| Pre-Season | |
| San Francisco Sea Lions | Bad Reputation |
|
Round 6, 10th Pick (SP Kyle Harrison SF) |
SS
Anthony Volpe
NYA |
| Pre-Season | |
| San Francisco Sea Lions | Don Mattingly |
|
SS
Anthony Volpe
NYA Round 10, 10th Pick (OF Nelson Velazquez KC) |
OF
Eloy Jimenez
ChA OF Jarred Kelenic Atl OF James Wood Was |
| Pre-Season | |
| San Francisco Sea Lions | Whiz Kids |
|
Round 3, 10th Pick (1B Andrew Vaughn ChA) |
Round 7, 1st Pick (1B Michael Busch ChN) |
| Week 6 | |
| San Francisco Sea Lions | Don Mattingly |
|
RP
Kirby Yates
Tex 2B Jordan Westburg Bal |
2B
Xander Bogaerts
SD SP Cristopher Sanchez Phi OF Jasson Dominguez NYA SS Anthony Volpe NYA |
| Week 7 | |
| San Francisco Sea Lions | The Plantation |
|
RP
Kenley Jansen
Bos |
2B
Luis Arraez
SD |