| Week | Add | Drop |
| Pre-Season |
Round 1: SP Reese Olson - Det Round A: SP Yoshinobu Yamamoto - LAD Round B: C Bo Naylor - Cle Round C: SP Trevor Bauer - LAD Round D: SS Colson Montgomery - ChA |
Round 1: SP Bryan Woo - Sea Round A: SP Kyle Wright - KC Round B: C Tyler Soderstrom - Oak Round C: OF Everson Pereira - NYA |
| Week 1 |
Round 1: SP Jared Jones - Pit Round 2: 2B Brendan Donovan - StL | |
| Week 2 |
Round 1: SP Spencer Turnbull - Phi Round 2: OF Joey Gallo - Was |
Round 1: SP AJ Puk - Mia Round 2: 1B Jake Cronenworth - SD |
| Week 3 |
Round 1: C Ivan Herrera - StL Round 2: OF Blake Perkins - Mil |
Round 1: C Alejandro Kirk - Tor |
| Week 4 |
Round 1: SP Edward Cabrera - Mia Round 2: OF Daulton Varsho - Tor |
Round 1: OF Joey Gallo - Was Round 2: SP Triston McKenzie - Cle |
| Week 5 |
Round 1: RP Joel Payamps - Mil Round 2: SP Bryan Woo - Sea |
Round 1: SP Spencer Turnbull - Phi Round 2: C Ivan Herrera - StL |
| Week 6 |
Round 1: C Luis Campusano - SD Round 2: OF Wenceel Perez - Det |
Round 1: RP Joel Payamps - Mil Round 2: OF Parker Meadows - Det |
| 1st Team | 2nd Team |
| Pre-Season | |
| Midnight Run | Deputy Dawg |
|
SP
Yoshinobu Yamamoto
LAD |
RP
Edwin Diaz
NYN |
| Pre-Season | |
| Midnight Run | Tennessee Rats |
|
Round 5, 1st Pick (1B Jeimer Candelario Cin) |
RP
Devin Williams
Mil |
| Pre-Season | |
| Midnight Run | New Orleans Crescent Stars |
|
OF
Jazz Chisholm
Mia |
Round 2, 4th Pick (SP Jesus Luzardo Mia) |
| Pre-Season | |
| Midnight Run | Sussex County Miners |
|
OF
Jasson Dominguez
NYA SS Junior Caminero TB |
1B
Anthony Rizzo
NYA Round 8, 3rd Pick (SP Triston McKenzie Cle) |
| Pre-Season | |
| Midnight Run | Mary & Mart |
|
Round 1, 1st Pick (OF Seiya Suzuki ChN) |
OF
Wyatt Langford
Tex |
| Pre-Season | |
| Midnight Run | Sussex County Miners |
|
3B
Coby Mayo
Bal |
Round 10, 3rd Pick (SP Luis Severino NYN) |
| Pre-Season | |
| Midnight Run | Bernie Williams |
|
OF
Riley Greene
Det |
SP
Blake Snell
SF |
| Pre-Season | |
| Midnight Run | Deputy Dawg |
|
2B
Colt Keith
Det |
SP
Bryce Miller
Sea |
| Pre-Season | |
| Midnight Run | Bernie Williams |
|
SP
Blake Snell
SF C Francisco Álvarez NYN |
RP
Emmanuel Clase
Cle |
| Pre-Season | |
| Midnight Run | Tennessee Rats |
|
OF
Jackson Chourio
Mil |
Round 1, 8th Pick (OF Christopher Morel ChN) |
| Pre-Season | |
| Midnight Run | Deputy Dawg |
|
SP
Tanner Bibee
Cle |
Round 8, 2nd Pick (SP Marcus Stroman NYA) |
| Pre-Season | |
| Midnight Run | Sussex County Miners |
|
SP
Eury Perez
Mia |
Round 3, 3rd Pick (SP Gavin Williams Cle) |
| Pre-Season | |
| Midnight Run | NYSE: XOM |
|
SP
Walker Buehler
LAD |
Round 8, 12th Pick (SP Bryan Woo Sea) |
| Week 6 | |
| Midnight Run | Tennessee Rats |
|
2B
Nolan Gorman
StL RP Emmanuel Clase Cle |
OF
Josh Lowe
TB SP Nick Lodolo Cin |
| Week 6 | |
| Midnight Run | Sussex County Miners |
|
RP
Edwin Diaz
NYN |
SP
Jordan Hicks
SF |