| Week | Add | Drop |
| Pre-Season |
Round A: OF Evan Carter - Tex Round B: SP Ryan Pepiot - TB |
Round A: 1B Joey Votto - Tor Round B: SP Tommy Henry - Ari |
| Week 1 |
Round 1: 1B Jake Cronenworth - SD Round 2: RP Garrett Whitlock - Bos | |
| Week 3 |
Round 1: OF Edward Olivares - Pit Round 2: OF Brenton Doyle - Col |
Round 2: OF Jarred Kelenic - Atl |
| Week 4 |
Round 1: SP Graham Ashcraft - Cin Round 2: 2B Rob Refsnyder - Bos |
Round 1: OF Edward Olivares - Pit Round 2: OF Brenton Doyle - Col |
| Week 5 |
Round 1: OF Trevor Larnach - Min Round 2: SP Hayden Wesneski - ChN |
Round 1: SS Javier Baez - Det Round 2: OF Sal Frelick - Mil |
| Week 6 |
Round 1: 2B Luis Rengifo - LAA Round 2: SP Cole Irvin - Bal |
Round 1: RP Adbert Alzolay - ChN Round 2: OF Jung Hoo Lee - SF |
| Week 7 |
Round 1: SP Sean Manaea - NYN |
Round 1: 2B Luis Rengifo - LAA |
| Week 8 |
Round 1: SP Jonathan Gray - Tex Round 2: RP José Soriano - LAA |
Round 1: SP Hayden Wesneski - ChN Round 2: OF Trevor Larnach - Min |
| 1st Team | 2nd Team |
| Pre-Season | |
| NYSE: PG | Peoria Javelinas |
|
Round 10, 5th Pick (SP Jordan Wicks ChN) Round 11, 5th Pick (2B Jonathan Aranda TB) Round 12, 5th Pick (SP Nick Lodolo Cin) Round 13, 5th Pick (OF Matt Wallner Min) |
Round 7, 11th Pick (OF Jung Hoo Lee SF) |
| Pre-Season | |
| NYSE: PG | Josh Gallagher |
|
SP
Dane Dunning
Tex |
Round 3, 8th Pick (SP Chris Bassitt Tor) |
| Pre-Season | |
| NYSE: PG | Gittin Jazzy Wit it |
|
2B
Colt Keith
Det Round 14, 5th Pick (RP Mason Miller Oak) |
Round 7, 9th Pick (SP Andrew Abbott Cin) |
| Pre-Season | |
| NYSE: PG | Josh Gallagher |
|
SP
Kyle Hendricks
ChN |
Round 5, 8th Pick (1B Jeimer Candelario Cin) |
| Pre-Season | |
| NYSE: PG | Deputy Dawg |
|
RP
Will Smith
KC |
Round 1, 7th Pick (RP Raisel Iglesias Atl) Round 3, 7th Pick (C Logan O'Hoppe LAA) Round 5, 7th Pick (DH J.D. Martinez NYN) |
| Pre-Season | |
| NYSE: PG | Peoria Javelinas |
|
3B
Carter Kieboom
Was |
Round 1, 11th Pick (1B Nate Lowe Tex) Round 2, 11th Pick (SP Chris Sale Atl) Round 3, 11th Pick (SS J.P. Crawford Sea) Round 5, 11th Pick (OF Lourdes Gurriel Ari) |
| Pre-Season | |
| NYSE: PG | Gittin Jazzy Wit it |
|
1B
Joey Meneses
Was |
Round 8, 9th Pick (SS Javier Baez Det) |
| Pre-Season | |
| NYSE: PG | THE 700 LEVEL |
|
Round 3, 11th Pick (SS J.P. Crawford Sea) |
SP
Tyler Glasnow
LAD |
| Pre-Season | |
| NYSE: PG | Deputy Dawg |
|
Round 5, 11th Pick (OF Lourdes Gurriel Ari) |
OF
Bryan Reynolds
Pit |
| Week 7 | |
| NYSE: PG | Peoria Javelinas |
|
SS
Bo Bichette
Tor OF Evan Carter Tex |
SP
Max Fried
Atl 1B Christian Walker Ari OF Adolis Garcia Tex |
| Week 7 | |
| NYSE: PG | Up Your Butt Jobu |
|
1B
Nate Lowe
Tex |
OF
Brent Rooker
Oak |
| Week 7 | |
| NYSE: PG | Deputy Dawg |
|
OF
Josh Lowe
TB |
RP
Robert Suarez
SD |