| Week | Add | Drop |
| Pre-Season |
Round 1: SP Garrett Crochet - ChA Round 2: OF Dominic Canzone - Sea Round A: 3B Coby Mayo - Bal Round B: SP Trevor Bauer - LAD Round C: 3B Yoan Moncada - ChA Round D: C Austin Wells - NYA |
Round 1: OF Garrett Mitchell - Mil Round A: OF Nick Martini - Cin Round B: C Elias Diaz - Col |
| Week 1 |
Round 1: OF Edward Olivares - Pit Round 2: 2B Brendan Donovan - StL | |
| Week 2 |
Round 1: SP Graham Ashcraft - Cin Round 2: OF Joey Gallo - Was |
Round 2: 1B Jose Abreu - Hou |
| Week 3 |
Round 1: SP Yariel Rodriguez - Tor Round 2: OF Blake Perkins - Mil |
Round 1: OF Dominic Canzone - Sea Round 2: 2B Bryson Stott - Phi |
| Week 4 |
Round 1: SP Edward Cabrera - Mia Round 2: SS Gabriel Arias - Cle |
Round 1: SP AJ Puk - Mia Round 2: OF Edward Olivares - Pit |
| Week 5 |
Round 1: OF Wilyer Abreu - Bos Round 2: 3B Nick Senzel - Was |
Round 1: 3B Yoan Moncada - ChA Round 2: OF Joey Gallo - Was |
| Week 6 |
Round 1: SP Alek Manoah - Tor Round 2: 2B Luis Garcia - Was |
Round 1: OF Blake Perkins - Mil Round 2: SS Gabriel Arias - Cle |
| 1st Team | 2nd Team |
| Pre-Season | |
| Louisville Sluggers | Norfolk Tides |
|
2B
Matt McLain
Cin |
OF
Kyle Schwarber
Phi |
| Pre-Season | |
| Louisville Sluggers | Quaranteam |
|
RP
Jordan Romano
Tor |
Round 3, 5th Pick (SP Brayan Bello Bos) |
| Pre-Season | |
| Louisville Sluggers | Vermont Lake Monsters |
|
3B
Royce Lewis
Min |
Round 1, 2nd Pick (1B Anthony Rizzo NYA) |
| Pre-Season | |
| Louisville Sluggers | Built 4 Speed |
|
OF
Jackson Chourio
Mil |
SP
Eury Perez
Mia |
| Pre-Season | |
| Louisville Sluggers | Auburn Doubledays |
|
3B
Coby Mayo
Bal |
Round 8, 7th Pick (C Henry Davis Pit) |
| Pre-Season | |
| Louisville Sluggers | Zack Attack |
|
Round 7, 9th Pick (DH Justin Turner Tor) |
C
Yainer Diaz
Hou |
| Pre-Season | |
| Louisville Sluggers | Chin Music |
|
Round 4, 9th Pick (3B Jake Burger Mia) |
3B
Isaac Paredes
TB |
| Pre-Season | |
| Louisville Sluggers | Auburn Doubledays |
|
RP
Devin Williams
Mil |
OF
Jarren Duran
Bos |
| Pre-Season | |
| Louisville Sluggers | Built 4 Speed |
|
SS
Jackson Holliday
Bal |
OF
Jackson Chourio
Mil |