| Week | Add | Drop |
| Pre-Season |
Round 1: SP Mike Soroka - ChA Round 2: RP Yimi Garcia - Tor |
Round 1: SP Nick Lodolo - Cin |
| Week 1 |
Round 1: RP Michael Kopech - ChA Round 2: RP Ronel Blanco - Hou | |
| Week 2 |
Round 1: SP Dane Dunning - Tex Round 2: RP David Robertson - Tex |
Round 1: RP Yimi Garcia - Tor Round 2: SP Mike Soroka - ChA Round 2: SP AJ Puk - Mia |
| Week 3 |
Round 1: SP Yariel Rodriguez - Tor Round 2: SS Jose Caballero - TB |
Round 1: 3B Curtis Mead - TB Round 2: SP Yariel Rodriguez - Tor |
| Week 4 |
Round 1: SP Yariel Rodriguez - Tor Round 2: RP Garrett Whitlock - Bos |
Round 2: RP David Robertson - Tex |
| Week 5 |
Round 1: RP Orion Kerkering - Phi Round 2: RP Yennier Cano - Bal |
Round 1: RP Michael Kopech - ChA Round 2: SP Yariel Rodriguez - Tor |
| Week 6 |
Round 1: SP Casey Mize - Det Round 2: C Connor Wong - Bos |
Round 1: RP Yennier Cano - Bal Round 2: C Henry Davis - Pit |
| 1st Team | 2nd Team |
| Pre-Season | |
| Hit for the Cycle | 35 GAMERS. |
|
SP
Pablo Lopez
Min |
Round 9, 5th Pick (SP Shota Imanaga ChN) |
| Pre-Season | |
| Hit for the Cycle | Wasco Reserve |
|
OF
Eloy Jimenez
ChA |
Round 5, 6th Pick (1B Kyle Manzardo Cle) |
| Pre-Season | |
| Hit for the Cycle | Deputy Dawg |
|
SP
Lucas Giolito
Bos |
Round 9, 1st Pick (OF Jung Hoo Lee SF) |
| Pre-Season | |
| Hit for the Cycle | Deputy Dawg |
|
SP
Logan Gilbert
Sea |
Round 6, 1st Pick (SP Gavin Williams Cle) |
| Week 5 | |
| Hit for the Cycle | Wasco Reserve |
|
OF
Tyler O'Neill
Bos OF Mitch Haniger Sea |
SP
Cole Ragans
KC RP Andres Munoz Sea |