| Week | Add | Drop |
| Pre-Season |
Round 1: RP Jose Leclerc - Tex Round 2: C Tyler Stephenson - Cin |
Round 1: 3B Elehuris Montero - Col |
| Week 1 |
Round 1: RP Jason Foley - Det Round 2: 3B Trey Lipscomb - Was |
Round 1: RP Jose Leclerc - Tex Round 2: SP Luis Gil - NYA |
| Week 2 |
Round 1: SP Reid Detmers - LAA Round 2: SP Christian Scott - NYN |
Round 1: 3B Anthony Rendon - LAA Round 2: SP J.P. France - Hou |
| Week 3 |
Round 1: RP James McArthur - KC Round 2: SP Kyle Bradish - Bal |
Round 2: 2B Luis Arraez - SD |
| Week 4 |
Round 1: OF Andy Pages - LAD Round 2: SS Jose Caballero - TB |
Round 2: 3B Trey Lipscomb - Was |
| Week 5 |
Round 1: OF Bryan De La Cruz - Mia Round 2: RP Kevin Ginkel - Ari |
Round 1: SP Michael Wacha - KC Round 2: OF Parker Meadows - Det |
| Week 6 |
Round 1: OF Austin Martin - Min |
Round 1: OF Jarred Kelenic - Atl |
| Week 7 |
Round 2: 1B Carlos Santana - Min |
Round 2: OF Austin Martin - Min |
| 1st Team | 2nd Team |
| Pre-Season | |
| Mike Krupa | Whiz Kids |
|
3B
Eugenio Suarez
Ari |
RP
Kenley Jansen
Bos |
| Pre-Season | |
| Mike Krupa | Winning is Contagious |
|
3B
Ke'Bryan Hayes
Pit 1B Vladimir Guerrero Jr Tor SS Ezequiel Tovar Col |
SS
Ha-seong Kim
SD SS Elly De La Cruz Cin |
| Pre-Season | |
| Mike Krupa | Whiz Kids |
|
SS
Ha-seong Kim
SD |
2B
Zack Gelof
Oak |
| Week 5 | |
| Mike Krupa | Philly Cheesesteaks |
|
SP
Seth Lugo
KC 1B Nate Lowe Tex |
SP
Yu Darvish
SD 3B Nolan Arenado StL |
| Week 5 | |
| Mike Krupa | Bleacher Bums |
|
1B
Spencer Torkelson
Det RP James McArthur KC |
OF
Teoscar Hernández
LAD 2B Luis Arraez Mia |