| Week | Add | Drop |
| Pre-Season |
Round 1: C Gary Sanchez - Mil Round 2: SS Oswaldo Cabrera - NYA Round A: SP AJ Smith-Shawver - Atl Round B: SP Cade Horton - ChN Round C: 1B Kris Bryant - Col Round D: SP Alek Manoah - Tor |
Round A: SS Amed Rosario - TB Round B: 2B Michael Massey - KC Round C: 1B Ty France - Sea Round D: OF Hunter Goodman - Col |
| Week 1 |
Round 1: RP Jason Foley - Det | |
| Week 3 |
Round 1: SP Yariel Rodriguez - Tor Round 2: SS Jose Caballero - TB |
Round 1: SP Josiah Gray - Was |
| Week 4 |
Round 1: OF Andy Pages - LAD Round 2: SP Jonathan Gray - Tex |
Round 1: SP J.P. France - Hou Round 2: OF Parker Meadows - Det |
| Week 5 |
Round 1: OF Ceddanne Rafaela - Bos Round 2: SP Keaton Winn - SF |
Round 2: SP Jordan Wicks - ChN |
| Week 6 |
Round 1: OF Austin Beck - LAD Round 2: SP Simeon Woods Richardson - Min |
Round 1: RP Tanner Scott - Mia Round 2: OF Austin Beck - LAD Round 2: SP Yariel Rodriguez - Tor |
| Week 7 |
Round 1: SP Sean Manaea - NYN |
Round 1: SP Jonathan Gray - Tex |
| 1st Team | 2nd Team |
| Pre-Season | |
| Buffalo Yankees | Gizzy |
|
Round 6, 9th Pick (3B Matt Chapman SF) |
2B
Zack Gelof
Oak 1B Kyle Manzardo Cle Round 19, 1st Pick (SP Reid Detmers LAA) |
| Pre-Season | |
| Buffalo Yankees | Chaos Creators |
|
Round 3, 9th Pick (C Cal Raleigh Sea) |
3B
Noelvi Marte
Cin Round 10, 8th Pick (OF Parker Meadows Det) |
| Pre-Season | |
| Buffalo Yankees | Gizzy |
|
Round 9, 9th Pick (SP Bryce Elder Atl) |
RP
Michael Kopech
ChA |