| Week | Add | Drop |
| Pre-Season |
Round 1: SS Gavin Lux - LAD Round 2: RP James McArthur - KC Round A: OF Jung Hoo Lee - SF Round B: RP Ryan Helsley - StL Round C: SS Gavin Lux - LAD Round D: SS Marcelo Mayer - Bos |
Round A: SS Osleivis Basabe - TB Round B: C Shea Langeliers - Oak |
| Week 1 |
Round 1: SP Dean Kremer - Bal Round 2: SP Ricky Tiedemann - Tor |
Round 2: SS Gavin Lux - LAD |
| Week 2 |
Round 1: SP AJ Smith-Shawver - Atl Round 2: SS David Hamilton - Bos |
Round 1: OF Daulton Varsho - Tor Round 2: C Austin Wells - NYA |
| Week 3 |
Round 1: SP Christian Scott - NYN Round 2: 2B Jace Jung - Det |
Round 1: SS David Hamilton - Bos Round 2: SS Brayan Rocchio - Cle |
| Week 4 |
Round 1: SP Yariel Rodriguez - Tor Round 2: 3B Orelvis Martinez - Tor | |
| Week 5 |
Round 1: OF Trevor Larnach - Min Round 2: RP Yennier Cano - Bal |
Round 1: SP Ricky Tiedemann - Tor Round 2: SS Colson Montgomery - ChA |
| Week 6 |
Round 1: SP Cade Horton - ChN Round 2: SP Luis Gil - NYA |
Round 1: RP Yennier Cano - Bal Round 2: 1B Nolan Schanuel - LAA |
| Week 7 |
Round 1: SP Robert Gasser - Mil Round 2: OF Wenceel Perez - Det |
Round 2: OF Jung Hoo Lee - SF |
| Week 8 |
Round 1: 2B Nick Gonzales - Pit Round 2: SS Marco Luciano - SF |
Round 1: C Henry Davis - Pit Round 2: SP AJ Smith-Shawver - Atl Round 2: SP Cade Horton - ChN |
| Week 9 |
Round 1: SP Cade Povich - Bal Round 1: SP Cade Povich - Bal Round 2: C Connor Wong - Bos |
Round 2: RP Michael Kopech - LAD |
| Week 10 |
Round 1: RP Reed Garrett - NYN Round 2: 1B Joey Meneses - Was |
Round 1: SP Yariel Rodriguez - Tor Round 2: SP Casey Mize - Det |
| Week 11 |
Round 1: 1B Andrew Vaughn - ChA Round 2: C Samuel Basallo - Bal |
Round 1: SP Robert Gasser - Mil Round 2: RP Reed Garrett - NYN |
| Week 12 |
Round 1: 1B Spencer Horwitz - Tor Round 2: SS David Hamilton - Bos |
Round 1: C Bo Naylor - Cle Round 2: 1B Joey Meneses - Was Round 2: SP Jackson Jobe - Det |
| Week 13 |
Round 1: SS Brooks Lee - Min Round 2: RP Jason Foley - Det |
Round 2: 3B Orelvis Martinez - Tor |
| Week 14 |
Round 1: OF Cedric Mullins - Bal Round 2: 1B Ben Rice - NYA |
Round 1: SS Marco Luciano - SF Round 2: RP Jason Foley - Det |
| Week 15 |
Round 1: SS Jacob Wilson - Oak Round 2: 3B Daniel Schneemann - Cle |
Round 1: OF Wenceel Perez - Det Round 2: SS David Hamilton - Bos |
| Week 16 |
Round 1: 2B Travis Bazzana - Cle Round 2: OF Lawrence Butler - Oak |
Round 1: C Samuel Basallo - Bal Round 2: SS Jacob Wilson - Oak |
| Week 17 |
Round 2: SP Cade Povich - Bal | |
| Week 18 |
Round 1: SP River Ryan - LAD Round 2: C Austin Wells - NYA |
Round 2: 2B Nick Gonzales - Pit |
| Week 19 |
Round 1: SP Hayden Birdsong - SF Round 2: SS Gavin Lux - LAD |
Round 1: SP Christian Scott - NYN Round 2: 3B Daniel Schneemann - Cle |
| Week 20 |
Round 1: RP Justin Martinez - Ari Round 2: RP Ryan Walker - SF |
Round 1: SP Hayden Birdsong - SF Round 2: SS Brooks Lee - Min |
| Week 22 |
Round 1: SP Simeon Woods Richardson - Min Round 2: SP David Peterson - NYN |
Round 1: RP James McArthur - KC Round 2: OF Cedric Mullins - Bal |
| 1st Team | 2nd Team |
| Pre-Season | |
| Blue Jays | Miami Giants |
|
Round 2, 11th Pick (SP Gavin Williams Cle) |
1B
Spencer Torkelson
Det |
| Pre-Season | |
| Blue Jays | Ground Rule Double |
|
Round 6, 11th Pick (SP Kodai Senga NYN) |
SP
Grayson Rodriguez
Bal |
| Pre-Season | |
| Blue Jays | Bad Reputation |
|
SP
Blake Snell
SF |
Round 6, 1st Pick (SP Bailey Ober Min) |