| Week | Add | Drop |
| Pre-Season |
Round 2: SP Wade Miley - Mil | |
| Week 1 |
Round 1: SP Kenta Maeda - Det | |
| Week 2 |
Round 1: SP Javier Assad - ChN | |
| Week 3 |
Round 2: SP Tyler Anderson - LAA |
Round 2: SP Sandy Alcántra - Mia |
| Week 4 |
Round 1: SP Colin Rea - Mil |
Round 1: SP Mike Clevinger - ChA |
| Week 5 |
Round 1: RP Reed Garrett - NYN |
Round 1: SP Shane McClanahan - TB |
| Week 7 |
Round 1: SP Cole Irvin - Min Round 2: SP Sean Manaea - NYN |
Round 1: SP Kenta Maeda - Det Round 2: RP Reed Garrett - NYN |
| Week 8 |
Round 1: OF Brenton Doyle - Col |
Round 1: DH Mitch Garver - Sea |
| Week 9 |
Round 1: SP Austin Gomber - Col Round 1: SP Austin Gomber - Col |
Round 1: SP Jose Quintana - NYN Round 1: SP Jose Quintana - NYN |
| Week 13 |
Round 1: 1B Michael Toglia - Col |
Round 1: 1B Kris Bryant - Col |
| Week 14 |
Round 1: RP Hector Neris - Hou Round 2: 2B Rob Refsnyder - Bos |
Round 1: SP Austin Gomber - Col Round 2: SP Eury Perez - Mia |
| 1st Team | 2nd Team |