| Week | Add | Drop |
| Pre-Season |
Round 1: SP Jack Flaherty - Det Round 2: OF Mickey Moniak - LAA | |
| Week 1 |
Round 1: OF Starling Marte - NYN Round 2: 1B Jared Walsh - ChA |
Round 1: OF Mickey Moniak - LAA |
| Week 2 |
Round 1: RP José Alvarado - Phi Round 2: SP Graham Ashcraft - Cin |
Round 1: SP Kyle Hendricks - ChN Round 2: SP Kenta Maeda - Det |
| Week 3 |
Round 1: OF Gavin Sheets - ChA Round 2: SS Blaze Alexander - Ari |
Round 1: 1B Jared Walsh - ChA Round 2: SS Javier Baez - Det |
| Week 4 |
Round 1: SP Jameson Taillon - ChN |
Round 1: RP José Alvarado - Phi Round 2: OF Gavin Sheets - ChA |
| Week 5 |
Round 1: RP Hector Neris - ChN Round 2: OF Jo Adell - LAA | |
| Week 6 |
Round 1: OF Jurickson Profar - SD Round 2: OF Dylan Carlson - StL |
Round 2: 1B Joshua Bell - Mia |
| Week 7 |
Round 1: SP Robert Gasser - Mil |
Round 1: OF Sal Frelick - Mil |
| 1st Team | 2nd Team |
| Pre-Season | |
| Bottom of the pack 7 | Quad Cities River Bandits |
|
OF
Spencer Steer
Cin |
Round 4, 3rd Pick (2B Xander Bogaerts SD) |
| Pre-Season | |
| Bottom of the pack 7 | Quad Cities River Bandits |
|
3B
Jose Ramirez
Cle |
2B
Marcus Semien
Tex Round 5, 3rd Pick (OF Brandon Nimmo NYN) |
| Pre-Season | |
| Bottom of the pack 7 | Philippians |
|
Round 4, 10th Pick (SP Triston McKenzie Cle) Round 6, 10th Pick (3B Ryan McMahon Col) |
SP
Cole Ragans
KC |
| Pre-Season | |
| Bottom of the pack 7 | Las Vegas 51's |
|
2B
Gleyber Torres
NYA |
Round 7, 8th Pick (SP Marcus Stroman NYA) |
| Pre-Season | |
| Bottom of the pack 7 | The Plantation |
|
SS
Carlos Correa
Min |
Round 4, 1st Pick (RP Peter Fairbanks TB) |
| Pre-Season | |
| Bottom of the pack 7 | The Plantation |
|
Round 1, 10th Pick (OF Jorge Soler SF) Round 3, 10th Pick (RP Craig Kimbrel Bal) |
RP
Will Smith
KC |