| Week | Add | Drop |
| Pre-Season |
Round 1: SP Chase Silseth - LAA Round 2: C Tyler Stephenson - Cin Round A: SP Shota Imanaga - ChN Round B: OF Brian Goodwin - F/A |
Round A: C Alejandro Kirk - Tor Round B: 1B Seth Brown - Oak |
| Week 1 |
Round 2: 3B Curtis Mead - TB | |
| Week 2 |
Round 1: SP Max Meyer - Mia Round 2: OF Micahel Taylor - Pit | |
| Week 3 |
Round 1: SP Spencer Turnbull - Phi Round 2: 3B Josh Smith - Tex |
Round 2: 3B Mark Vientos - NYN |
| Week 4 |
Round 1: OF Esteury Ruiz - Oak |
Round 1: SP Ryne Nelson - Ari |
| Week 5 |
Round 1: RP José Alvarado - Phi Round 2: OF Gavin Sheets - ChA |
Round 2: OF Micahel Taylor - Pit |
| Week 6 |
Round 2: 3B Patrick Wisdom - ChN |
Round 2: SP Chase Silseth - LAA |
| Week 7 |
Round 1: 1B Jonathan Singleton - Hou Round 2: 3B Brett Harris - Oak |
Round 1: 3B Curtis Mead - TB Round 2: RP Adbert Alzolay - ChN |
| 1st Team | 2nd Team |
| Pre-Season | |
| Las Vegas 51's | Built 4 Speed |
|
Round 3, 8th Pick (SP Shane Bieber Cle) |
3B
Noelvi Marte
Cin |
| Pre-Season | |
| Las Vegas 51's | Ron Guidry |
|
SS
Bo Bichette
Tor Round 18, 12th Pick (OF Nelson Velazquez KC) |
OF
Wyatt Langford
Tex Round 5, 7th Pick (RP Paul Sewald Ari) |
| Pre-Season | |
| Las Vegas 51's | Pirates |
|
Round 1, 8th Pick (SP Chris Sale Atl) Round 2, 8th Pick (RP Evan Phillips LAD) Round 4, 8th Pick (SP Kyle Harrison SF) |
OF
Mike Trout
LAA Round 18, 12th Pick (OF Nelson Velazquez KC) Round 19, 12th Pick (SP Tanner Houck Bos) |
| Pre-Season | |
| Las Vegas 51's | Bottom of the pack 7 |
|
Round 7, 8th Pick (SP Marcus Stroman NYA) |
2B
Gleyber Torres
NYA |