| Week | Add | Drop |
| Pre-Season |
Round 1: RP Michael Kopech - LAD Round 2: C Elias Diaz - SD | |
| Week 2 |
Round 1: 2B Brendan Donovan - StL Round 2: SP Paul Blackburn - NYN | |
| Week 3 |
Round 1: SP Tyler Anderson - LAA Round 2: C Ivan Herrera - StL | |
| Week 4 |
Round 1: RP Kirby Yates - Tex Round 2: OF Daulton Varsho - Tor | |
| Week 5 |
Round 1: OF Wilyer Abreu - Bos Round 2: 3B Tyler Black - Mil | |
| Week 6 |
Round 1: 2B Willi Castro - Min Round 2: SS Gavin Lux - LAD |
Round 2: SP Matt Manning - Det |
| Week 7 |
Round 1: SP Taj Bradley - TB Round 2: 2B Thomas Saggese - StL |
Round 1: RP Griffin Jax - Min Round 2: SP Edward Cabrera - Mia |
| Week 8 |
Round 1: OF JJ Bleday - Oak Round 2: 1B Jake Bauers - Mil |
Round 1: OF TJ Friedl - Cin Round 2: OF James Outman - LAD |
| Week 9 |
Round 1: SS Carson Williams - TB Round 1: SS Carson Williams - TB |
Round 1: SP Jose Quintana - NYN Round 1: SP Jose Quintana - NYN |
| Week 10 |
Round 1: 3B Brady House - Was Round 2: SP Austin Gomber - Col |
Round 1: SP Paul Blackburn - NYN |
| Week 11 |
Round 1: 3B Tyler Locklear - Sea Round 2: SP Jake Irvin - Was |
Round 1: SP Reid Detmers - LAA Round 2: 2B Jonathan Aranda - TB |
| Week 12 |
Round 1: SP Cade Povich - Bal Round 2: SP David Peterson - NYN |
Round 1: 1B Kris Bryant - Col Round 2: C Elias Diaz - SD |
| Week 13 |
Round 1: OF MJ Melendez - KC Round 2: C Bo Naylor - Cle |
Round 1: SP Austin Gomber - Col Round 2: C Ivan Herrera - StL |
| Week 14 |
Round 1: 1B Jhonkensy Noel - Cle |
Round 1: SS Gavin Lux - LAD |
| Week 15 |
Round 1: OF Colby Thomas - Oak |
Round 1: OF MJ Melendez - KC |
| Week 16 |
Round 1: SS Shay Whitcomb - Hou |
Round 1: SP Cade Povich - Bal |
| Week 18 |
Round 1: SP Jacob deGrom - Tex Round 2: SP Jeffrey Springs - TB |
Round 1: SP Logan Allen - Cle |
| Week 19 |
Round 1: SP Shane McClanahan - TB Round 2: RP Mason Miller - Oak |
Round 1: SP Jonathan Gray - Tex Round 2: 3B Tyler Locklear - Sea |
| Week 20 |
Round 1: SP Merrill Kelly - Ari Round 2: OF Lazaro Montes - Sea |
Round 1: 1B Jake Bauers - Mil Round 2: SP David Peterson - NYN |
| Week 22 |
Round 1: SP Andrew Painter - Phi Round 2: SP Kumar Rocker - Tex |
Round 1: OF Jose Siri - TB Round 2: SP Reese Olson - Det |
| 1st Team | 2nd Team |
| Pre-Season | |
| Billings Mustangs | Philippians |
|
Round 1, 11th Pick (OF Teoscar Hernández LAD) Round 3, 11th Pick (2B Brandon Lowe TB) Round 4, 11th Pick (SS Jeremy Pena Hou) Round 5, 11th Pick (C Jonah Heim Tex) Round 7, 11th Pick (SS Trevor Story Bos) Round 9, 11th Pick (SS Wander Franco TB) |
SP
Jeffrey Springs
TB |
| Week 9 | |
| Billings Mustangs | Philippians |
|
SP
Freddy Peralta
Mil |
|
| Week 17 | |
| Billings Mustangs | Ron Guidry |
|
2B
Willi Castro
Min SS Ezequiel Tovar Col 2B Zack Gelof Oak SP Taj Bradley TB |
SS
Bo Bichette
Tor OF Roman Anthony Bos |
| Week 17 | |
| Billings Mustangs | Philippians |
|
OF
Giancarlo Stanton
NYA 2B Brendan Donovan StL |
SP
Jonathan Gray
Tex OF Jose Siri TB |
| Week 17 | |
| Billings Mustangs | New York Lincoln Giants |
|
2B
Thomas Saggese
StL |
SS
Ezequiel Tovar
Col |