| Week | Add | Drop |
| Pre-Season |
Round 1: RP Kevin Ginkel - Ari Round 2: 3B Elehuris Montero - Col Round A: 3B Coby Mayo - Bal Round B: SS Jackson Merrill - SD |
Round A: C Travis d'Arnaud - Atl Round B: C Sean Murphy - Atl |
| Week 1 |
Round 2: OF Micahel Taylor - Pit | |
| Week 2 |
Round 1: SP Spencer Turnbull - Phi Round 2: OF Charlie Blackmon - Col | |
| Week 3 |
Round 1: RP James McArthur - KC Round 2: 2B Thairo Estrada - SF | |
| Week 4 |
Round 1: SP Mike Lorenzen - Tex | |
| Week 5 |
Round 1: OF Daulton Varsho - Tor Round 2: SP Landon Knack - LAD |
Round 1: SP Matt Manning - Det |
| Week 6 |
Round 1: OF Max Kepler - Min Round 2: C Danny Jansen - Tor |
Round 1: RP Tyler Kinley - Col Round 2: 1B Ryan Noda - Oak |
| 1st Team | 2nd Team |
| Pre-Season | |
| Portland Sea Dogs | Twins Rock |
|
OF
Randy Arozarena
TB OF Lane Thomas Was |
Round 2, 7th Pick (SS C.J. Abrams Was) |
| Pre-Season | |
| Portland Sea Dogs | My Bad |
|
Round 4, 8th Pick (OF James Outman LAD) Round 9, 8th Pick (2B Jordan Westburg Bal) |
OF
Jasson Dominguez
NYA SS Anthony Volpe NYA |
| Pre-Season | |
| Portland Sea Dogs | Bad Reputation |
|
Round 2, 7th Pick (SS C.J. Abrams Was) Round 1, 8th Pick (RP Alexis Diaz Cin) Round 6, 8th Pick (1B Andrew Vaughn ChA) |
2B
Matt McLain
Cin |
| Pre-Season | |
| Portland Sea Dogs | Built 4 Speed |
|
Round 5, 8th Pick (SP Gavin Williams Cle) Round 11, 8th Pick (OF MJ Melendez KC) |
OF
Riley Greene
Det Round 14, 9th Pick (SP James Paxton LAD) Round 16, 9th Pick (SP Seth Lugo KC) |
| Pre-Season | |
| Portland Sea Dogs | The Plantation |
|
Round 3, 8th Pick (OF Jorge Soler SF) |
RP
Will Smith
KC |
| Week 4 | |
| Portland Sea Dogs | Bad Reputation |
|
C
Luis Campusano
SD |
OF
Dylan Crews
Was |