| Week | Add | Drop |
| Pre-Season |
Round 1: OF Mitch Haniger - Sea Round 2: OF Victor Scott - StL Round A: SP Robbie Ray - SF |
Round 2: SP Frankie Montas - Cin Round A: OF Hunter Renfroe - KC |
| Week 1 |
Round 2: SS Oswaldo Cabrera - NYA | |
| Week 2 |
Round 1: SP Nick Pivetta - Bos |
Round 1: SP Ryne Nelson - Ari |
| Week 3 |
Round 1: SP Colin Rea - Mil Round 2: OF Lane Thomas - Was |
Round 1: OF Victor Scott - StL |
| Week 4 |
Round 1: SP Mike Lorenzen - Tex Round 2: OF Starling Marte - NYN |
Round 2: 2B Wilmer Flores - SF |
| Week 5 |
Round 1: RP Joel Payamps - Mil Round 2: SP John Means - Bal |
Round 1: RP Aroldis Chapman - Pit Round 2: OF Lane Thomas - Was |
| Week 6 |
Round 1: C Patrick Bailey - SF Round 2: 2B Rob Refsnyder - Bos |
Round 1: RP Joel Payamps - Mil Round 2: SP Aaron Civale - TB Round 2: OF Sal Frelick - Mil Round 2: SP Andrew Heaney - Tex |
| Week 7 |
Round 1: SP Jameson Taillon - ChN Round 2: RP Griffin Jax - Min |
| 1st Team | 2nd Team |
| Pre-Season | |
| Memphis Red Sox | St. Paul Gophers |
|
Round 7, 4th Pick (OF Chas McCormick Hou) |
OF
Jorge Soler
SF |