| Week | Add | Drop |
| Pre-Season |
Round 1: SP Max Meyer - Mia Round 2: SS Marco Luciano - SF |
Round 2: SP Brandon Pfaadt - Ari |
| Week 1 |
Round 1: RP Abner Uribe - Mil Round 2: RP Ronel Blanco - Hou |
Round 2: RP Alex Lange - Det |
| Week 2 |
Round 1: SS Jordan Lawlar - Ari Round 2: 3B Trey Lipscomb - Was |
Round 1: SP Shane Bieber - Cle |
| Week 3 |
Round 1: SP Mitch Keller - Pit Round 2: RP David Robertson - Tex |
Round 1: SS Marco Luciano - SF Round 2: 1B Jose Abreu - Hou |
| Week 4 |
Round 1: OF Heston Kjerstad - Bal Round 2: SP Christian Scott - NYN |
Round 2: 3B Trey Lipscomb - Was |
| Week 5 |
Round 1: RP Orion Kerkering - Phi Round 2: RP Yennier Cano - Bal |
Round 1: RP David Robertson - Tex Round 2: RP Abner Uribe - Mil |
| Week 6 |
Round 1: RP Hector Neris - ChN Round 2: SP Kyle Gibson - StL |
Round 1: RP Yennier Cano - Bal Round 2: 1B Joey Meneses - Was |
| Week 7 |
Round 1: OF Blake Perkins - Mil |
Round 1: 3B Ezequiel Duran - Tex |
| 1st Team | 2nd Team |
| Pre-Season | |
| Horseheads Buffalos | Kannapolis Intimidators |
|
OF
Eloy Jimenez
ChA |
Round 6, 8th Pick (SP Carlos Rodon NYA) |
| Pre-Season | |
| Horseheads Buffalos | Hartford Yard Goats |
|
SP
Grayson Rodriguez
Bal |
Round 6, 10th Pick (SP Brayan Bello Bos) |
| Pre-Season | |
| Horseheads Buffalos | Ohio Gang |
|
C
Yainer Diaz
Hou |
Round 6, 1st Pick (C Logan O'Hoppe LAA) |
| Pre-Season | |
| Horseheads Buffalos | Hartford Yard Goats |
|
2B
Xander Bogaerts
SD Round 17, 11th Pick (C Freddy Fermin KC) Round 18, 11th Pick (SS Tim Anderson Mia) Round 19, 11th Pick (SP Kenta Maeda Det) |
Round 9, 10th Pick (SP Shota Imanaga ChN) |
| Week 6 | |
| Horseheads Buffalos | Kannapolis Intimidators |
|
3B
Josh Jung
Tex 1B Spencer Torkelson Det OF Jordan Walker StL SP Shota Imanaga ChN |
3B
Jose Ramirez
Cle SS Gavin Lux LAD OF Connor Joe Pit 2B Davis Schneider Tor |
| Week 6 | |
| Horseheads Buffalos | Putters Revenge |
|
SP
Bryce Miller
Sea |
1B
Paul Goldschmidt
StL |
| Week 6 | |
| Horseheads Buffalos | Levittown Pride |
|
OF
Corbin Carroll
Ari SP Max Meyer Mia OF Heston Kjerstad Bal 2B Jordan Westburg Bal SS Jordan Lawlar Ari |
1B
Joey Meneses
Was OF Julio Rodriguez Sea RP Jhoan Duran Min 3B Ezequiel Duran Tex OF Lars Nootbaar StL |