| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Gardner Minshew | QB | LV | 28 | Week 10 | ||
| Jordan Love | QB | GB | 25 | Week 10 | Questionable | Knee - MCL |
| Brock Purdy | QB | SF | 24 | Week 9 | ||
| Kenneth Gainwell | RB | Phi | 25 | Week 5 | ||
| Emari Demercado | RB | Ari | 25 | Week 11 | ||
| Saquon Barkley | RB | Phi | 27 | Week 5 | ||
| Raheem Mostert | RB | Mia | 32 | Week 6 | Questionable | Chest |
| David Montgomery | RB | Det | 27 | Week 5 | ||
| Cam Akers | RB | Hou | 25 | Week 14 | ||
| Tyler Johnson | WR | LAR | 26 | Week 6 | ||
| Darius Slayton | WR | NYG | 27 | Week 11 | ||
| Mike Evans | WR | TB | 31 | Week 11 | ||
| Amari Cooper | WR | Cle | 30 | Week 10 | ||
| Andrei Iosivas | WR | Cin | 24 | Week 12 | ||
| Christian Watson | WR | GB | 25 | Week 10 | ||
| Zay Flowers | WR | Bal | 24 | Week 14 | ||
| Sam LaPorta | TE | Det | 23 | Week 5 | ||
| Cameron Dicker | PK | LAC | 24 | Week 5 | ||
| Brandon Aubrey | PK | Dal | 29 | Week 7 | ||
| Khalil Mack | DL | LAC | 33 | Week 5 | ||
| Jared Verse | DL | LAR | 23 | Week 6 | ||
| Bradley Chubb | DL | Mia | 28 | Week 6 | PUP | Knee - ACL |
| Kwity Paye | DL | Ind | 25 | Week 14 | ||
| Odafe Oweh | DL | Bal | 25 | Week 14 | ||
| Roquan Smith | LB | Bal | 27 | Week 14 | ||
| Bobby Wagner | LB | Was | 34 | Week 14 | ||
| Lavonte David | LB | TB | 34 | Week 11 | ||
| Shaq Thompson | LB | Car | 30 | Week 11 | ||
| SirVocea Dennis | LB | TB | N/A | Week 11 | ||
| Devon Witherspoon | CB | Sea | 23 | Week 10 | Questionable | Hamstring |
| Kenny Moore | CB | Ind | 29 | Week 14 | ||
| Derwin James | S | LAC | 28 | Week 5 | ||
| Xavier McKinney | S | GB | 36 | Week 10 |