| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Geno Smith | QB | Sea | 33 | Week 10 | ||
| Tua Tagovailoa | QB | Mia | 26 | Week 6 | NFI | Concussion |
| Justin Fields | QB | Pit | 25 | Week 9 | ||
| Jonathon Brooks | RB | Car | 21 | Week 11 | NFI | Knee - ACL |
| Chuba Hubbard | RB | Car | 25 | Week 11 | ||
| Brian Robinson | RB | Was | 25 | Week 14 | ||
| Ty Chandler | RB | Min | 26 | Week 6 | ||
| Bijan Robinson | RB | Atl | 22 | Week 12 | ||
| Josh Palmer | WR | LAC | 24 | Week 5 | Questionable | Calf |
| Chris Olave | WR | NO | 24 | Week 12 | ||
| Zay Flowers | WR | Bal | 24 | Week 14 | ||
| Ladd McConkey | WR | LAC | 22 | Week 5 | ||
| D.J. Moore | WR | Chi | 27 | Week 7 | ||
| Rashod Bateman | WR | Bal | 24 | Week 14 | ||
| Tee Higgins | WR | Cin | 25 | Week 12 | Questionable | Hamstring |
| Noah Fant | TE | Sea | 26 | Week 10 | Questionable | Toe |
| Mike Gesicki | TE | Cin | 28 | Week 12 | ||
| Dalton Kincaid | TE | Buf | 25 | Week 12 | ||
| Jason Myers | PK | Sea | 33 | Week 10 | ||
| Josh Sweat | DL | Phi | 27 | Week 5 | ||
| Odafe Oweh | DL | Bal | 25 | Week 14 | ||
| Travon Walker | DL | Jac | 23 | Week 12 | ||
| Rashan Gary | DL | GB | 26 | Week 10 | ||
| Jamien Sherwood | LB | NYJ | 24 | Week 12 | ||
| K.J. Britt | LB | TB | 25 | Week 11 | ||
| Jack Campbell | LB | Det | 24 | Week 5 | ||
| David Long | LB | Mia | 27 | Week 6 | ||
| Kenneth Murray | LB | Ten | 25 | Week 5 | ||
| Ja'Whaun Bentley | LB | NE | 28 | Week 14 | Out | Pectoral |
| Robert Spillane | LB | LV | 28 | Week 10 | ||
| Mike Hilton | CB | Cin | 30 | Week 12 | ||
| Julian Blackmon | S | Ind | 26 | Week 14 | ||
| Antonio Johnson | S | Jac | N/A | Week 12 |