| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Derek Carr | QB | NO | 33 | Week 12 | ||
| Gardner Minshew | QB | LV | 28 | Week 10 | ||
| Joe Burrow | QB | Cin | 27 | Week 12 | ||
| Zamir White | RB | LV | 25 | Week 10 | ||
| J.K. Dobbins | RB | LAC | 25 | Week 5 | ||
| Zack Moss | RB | Cin | 26 | Week 12 | ||
| Christian McCaffrey | RB | SF | 28 | Week 9 | NFI | Achilles |
| Curtis Samuel | WR | Buf | 28 | Week 12 | ||
| Luke McCaffrey | WR | Was | 23 | Week 14 | ||
| D.K. Metcalf | WR | Sea | 26 | Week 10 | ||
| Alec Pierce | WR | Ind | 24 | Week 14 | ||
| Quentin Johnston | WR | LAC | 23 | Week 5 | ||
| Jordan Addison | WR | Min | 22 | Week 6 | Questionable | Ankle |
| Michael Pittman | WR | Ind | 26 | Week 14 | ||
| Pat Freiermuth | TE | Pit | 25 | Week 9 | ||
| Luke Musgrave | TE | GB | 24 | Week 10 | ||
| Hayden Hurst | TE | LAC | 31 | Week 5 | Questionable | Ankle |
| George Kittle | TE | SF | 30 | Week 9 | ||
| Harrison Butker | PK | KC | 29 | Week 6 | ||
| Dustin Hopkins | PK | Cle | 33 | Week 10 | ||
| Zaven Collins | DL | Ari | 25 | Week 11 | ||
| Keion White | DL | NE | N/A | Week 14 | ||
| Maxx Crosby | DL | LV | 27 | Week 10 | Questionable | Ankle |
| Will Anderson | DL | Hou | 23 | Week 14 | ||
| Aidan Hutchinson | DL | Det | 24 | Week 5 | ||
| Devin Lloyd | LB | Jac | 25 | Week 12 | ||
| Jeremiah Owusu-Koramoah | LB | Cle | 24 | Week 10 | ||
| Kaden Elliss | LB | Atl | 29 | Week 12 | ||
| Lavonte David | LB | TB | 34 | Week 11 | ||
| Roger McCreary | CB | Ten | 24 | Week 5 | ||
| Trent McDuffie | CB | KC | 24 | Week 6 | ||
| Talanoa Hufanga | S | SF | 25 | Week 9 | ||
| Chauncey Gardner-Johnson | S | Phi | 26 | Week 5 |