| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Caleb Williams | QB | Chi | 23 | No More Bye | ||
| C.J. Stroud | QB | Hou | 23 | No More Bye | ||
| Javonte Williams | RB | Den | 24 | No More Bye | ||
| Tyrone Tracy Jr. | RB | NYG | 25 | No More Bye | ||
| Kareem Hunt | RB | KC | 29 | No More Bye | Doubtful | Coach's Decision |
| Jonathan Taylor | RB | Ind | 25 | No More Bye | ||
| Antonio Gibson | RB | NE | 26 | No More Bye | ||
| Jakobi Meyers | WR | LV | 28 | No More Bye | ||
| Noah Brown | WR | Was | 29 | No More Bye | NFI | Torso |
| Ray-Ray McCloud | WR | Atl | 28 | No More Bye | ||
| Marvin Harrison Jr. | WR | Ari | 22 | No More Bye | ||
| Ladd McConkey | WR | LAC | 23 | No More Bye | ||
| Jalen Coker | WR | Car | 23 | No More Bye | ||
| Tyler Lockett | WR | Sea | 32 | No More Bye | ||
| Demarcus Robinson | WR | LAR | 30 | No More Bye | ||
| Drake London | WR | Atl | 24 | No More Bye | ||
| Tank Dell | WR | Hou | 25 | No More Bye | NFI | Knee - ACL |
| Parker Washington | WR | Jac | 22 | No More Bye | ||
| Andrei Iosivas | WR | Cin | 25 | No More Bye | ||
| Dalton Kincaid | TE | Buf | 26 | No More Bye | ||
| Pat Freiermuth | TE | Pit | 26 | No More Bye | ||
| Evan McPherson | PK | Cin | 25 | No More Bye | NFI | Groin |
| Gervon Dexter | DL | Chi | N/A | No More Bye | ||
| Boye Mafe | DL | Sea | 26 | No More Bye | ||
| Jonathon Cooper | DL | Den | 27 | No More Bye | ||
| D.J. Wonnum | DL | Car | 27 | No More Bye | ||
| Jordyn Brooks | LB | Mia | 27 | No More Bye | ||
| Bobby Okereke | LB | NYG | 28 | No More Bye | NFI | Back |
| Edgerrin Cooper | LB | GB | 23 | No More Bye | ||
| Bobby Wagner | LB | Was | 34 | No More Bye | ||
| Deommodore Lenoir | CB | SF | 25 | No More Bye | Out | Shoulder |
| Quentin Lake | S | LAR | N/A | No More Bye | ||
| Jessie Bates | S | Atl | 28 | No More Bye |