| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Jared Goff | QB | Det | 30 | No More Bye | ||
| Lamar Jackson | QB | Bal | 27 | Week 14 | Questionable | Knee |
| Jonathon Brooks | RB | Car | 21 | Week 11 | Questionable | Knee - ACL |
| MarShawn Lloyd | RB | GB | 23 | No More Bye | NFI | Ankle |
| Trey Benson | RB | Ari | 22 | Week 11 | ||
| Najee Harris | RB | Pit | 26 | No More Bye | ||
| Khalil Herbert | RB | Cin | 26 | Week 12 | ||
| Dameon Pierce | RB | Hou | 24 | Week 14 | Questionable | Groin |
| Ty Chandler | RB | Min | 26 | No More Bye | ||
| Jaylen Warren | RB | Pit | 26 | No More Bye | Questionable | Back |
| Tank Bigsby | RB | Jac | 23 | Week 12 | Questionable | Ankle |
| Josh Downs | WR | Ind | 23 | Week 14 | ||
| Jameson Williams | WR | Det | 23 | No More Bye | ||
| Malik Nabers | WR | NYG | 21 | Week 11 | ||
| D.J. Moore | WR | Chi | 27 | No More Bye | ||
| Tyreek Hill | WR | Mia | 30 | No More Bye | Questionable | Wrist |
| DJ Chark | WR | LAC | 28 | No More Bye | ||
| Jerry Jeudy | WR | Cle | 25 | No More Bye | ||
| Isaiah Likely | TE | Bal | 24 | Week 14 | ||
| Sam LaPorta | TE | Det | 23 | No More Bye | Questionable | Shoulder - AC Joint |
| Tyler Bass | PK | Buf | 27 | Week 12 | ||
| Jonathan Greenard | DL | Min | 27 | No More Bye | ||
| Arden Key | DL | Ten | N/A | No More Bye | ||
| Josh Sweat | DL | Phi | 27 | No More Bye | ||
| Haason Reddick | DL | NYJ | 30 | Week 12 | ||
| Derick Hall | DL | Sea | 23 | No More Bye | ||
| DeMarvion Overshown | LB | Dal | 24 | No More Bye | ||
| Ivan Pace | LB | Min | 23 | No More Bye | ||
| Jack Gibbens | LB | Ten | N/A | No More Bye | ||
| Zack Baun | LB | Phi | 27 | No More Bye | ||
| Cam Taylor-Britt | CB | Cin | 25 | Week 12 | ||
| Tyler Nubin | S | NYG | 23 | Week 11 | ||
| Demani Richardson | S | Car | 24 | Week 11 |