| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Baker Mayfield | QB | TB | 29 | Week 11 | ||
| Lamar Jackson | QB | Bal | 27 | Week 14 | ||
| James Conner | RB | Ari | 29 | Week 11 | ||
| Cordarrelle Patterson | RB | Pit | 33 | No More Bye | ||
| Ezekiel Elliott | RB | Dal | 29 | No More Bye | ||
| Antonio Gibson | RB | NE | 26 | Week 14 | ||
| Trey Sermon | RB | Ind | 25 | Week 14 | ||
| Isiah Pacheco | RB | KC | 25 | No More Bye | NFI | Ankle |
| Michael Pittman | WR | Ind | 27 | Week 14 | ||
| Demario Douglas | WR | NE | 23 | Week 14 | ||
| Demarcus Robinson | WR | LAR | 30 | No More Bye | ||
| Tyreek Hill | WR | Mia | 30 | No More Bye | ||
| Davante Adams | WR | NYJ | 31 | Week 12 | Questionable | Illness |
| Evan Engram | TE | Jac | 30 | Week 12 | ||
| Brock Bowers | TE | LV | 21 | No More Bye | ||
| Juwan Johnson | TE | NO | 28 | Week 12 | ||
| Chase McLaughlin | PK | TB | 28 | Week 11 | ||
| Jason Sanders | PK | Mia | 29 | No More Bye | ||
| Nick Bosa | DL | SF | 27 | No More Bye | Questionable | Hip |
| Montez Sweat | DL | Chi | 28 | No More Bye | Questionable | Ankle |
| Chris Jones | DL | KC | 30 | No More Bye | ||
| George Karlaftis | DL | KC | 23 | No More Bye | ||
| Byron Young | DL | LAR | 26 | No More Bye | Questionable | Knee |
| Dorian Williams | LB | Buf | 23 | Week 12 | ||
| Ernest Jones | LB | Sea | 24 | No More Bye | ||
| Jordyn Brooks | LB | Mia | 27 | No More Bye | ||
| Nick Bolton | LB | KC | 24 | No More Bye | ||
| C.J. Mosley | LB | NYJ | 32 | Week 12 | Out | Neck |
| Foyesade Oluokun | LB | Jac | 29 | Week 12 | ||
| Beanie Bishop Jr. | CB | Pit | 24 | No More Bye | ||
| Nate Hobbs | CB | LV | 25 | No More Bye | Out | Ankle |
| Jaquan Brisker | S | Chi | 25 | No More Bye | NFI | Concussion |
| Minkah Fitzpatrick | S | Pit | 28 | No More Bye |