| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Bo Nix | QB | Den | 24 | Week 14 | ||
| Kyler Murray | QB | Ari | 27 | Week 11 | ||
| Aaron Jones | RB | Min | 30 | No More Bye | Questionable | Ribs |
| Alvin Kamara | RB | NO | 29 | Week 12 | ||
| Javonte Williams | RB | Den | 24 | Week 14 | ||
| Kenneth Walker | RB | Sea | 24 | No More Bye | ||
| Roschon Johnson | RB | Chi | 23 | No More Bye | ||
| Keaton Mitchell | RB | Bal | 22 | Week 14 | ||
| Jaleel McLaughlin | RB | Den | 24 | Week 14 | ||
| Dontayvion Wicks | WR | GB | 23 | No More Bye | ||
| Jordan Addison | WR | Min | 22 | No More Bye | ||
| Chris Olave | WR | NO | 24 | Week 12 | NFI | Concussion |
| Xavier Worthy | WR | KC | 21 | No More Bye | ||
| Jerry Jeudy | WR | Cle | 25 | No More Bye | ||
| Darnell Mooney | WR | Atl | 27 | Week 12 | ||
| Elijah Moore | WR | Cle | 24 | No More Bye | ||
| A.J. Brown | WR | Phi | 27 | No More Bye | ||
| Taysom Hill | TE | NO | 34 | Week 12 | ||
| George Kittle | TE | SF | 31 | No More Bye | Questionable | Hamstring |
| Chris Boswell | PK | Pit | 33 | No More Bye | ||
| Za'Darius Smith | DL | Det | 32 | No More Bye | Questionable | personal |
| Joey Bosa | DL | LAC | 29 | No More Bye | ||
| Arden Key | DL | Ten | N/A | No More Bye | ||
| Zach Allen | DL | Den | 27 | Week 14 | ||
| Carl Granderson | DL | NO | 27 | Week 12 | ||
| Divine Deablo | LB | LV | 26 | No More Bye | ||
| Trenton Simpson | LB | Bal | 23 | Week 14 | ||
| Blake Cashman | LB | Min | 28 | No More Bye | ||
| Kaden Elliss | LB | Atl | 29 | Week 12 | ||
| Eric Kendricks | LB | Dal | 32 | No More Bye | ||
| Trevin Wallace | LB | Car | 21 | Week 11 | ||
| Alontae Taylor | CB | NO | N/A | Week 12 | ||
| Marte Mapu | S | NE | N/A | Week 14 |