| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Cameron Ward | QB | Ten | 23 | Week 10 | ||
| Jordan James | RB | SF | 21 | Week 14 | Finger | |
| DJ Giddens | RB | Ind | 22 | Week 11 | ||
| Oronde Gadsden | TE | LAC | 22 | Week 12 | ||
| Jacory Croskey-Merritt | RB | Was | 24 | Week 12 | ||
| Damien Martinez | RB | Sea | 21 | Week 8 | ||
| Daniel Jones | QB | Ind | 28 | Week 11 | ||
| Jalen Hurts | QB | Phi | 27 | Week 9 | ||
| Jonathan Taylor | RB | Ind | 26 | Week 11 | ||
| Nick Chubb | RB | Hou | 29 | Week 6 | ||
| Tyrone Tracy Jr. | RB | NYG | 25 | Week 14 | ||
| Isiah Pacheco | RB | KC | 26 | Week 10 | ||
| Roschon Johnson | RB | Chi | 24 | Week 5 | Questionable | Foot |
| Puka Nacua | WR | LAR | 24 | Week 8 | ||
| Brandon Aiyuk | WR | SF | 27 | Week 14 | PUP | Knee - ACL + MCL |
| Chris Olave | WR | NO | 25 | Week 11 | ||
| George Pickens | WR | Dal | 23 | Week 10 | ||
| Xavier Legette | WR | Car | 24 | Week 14 | ||
| Jauan Jennings | WR | SF | N/A | Week 14 | Questionable | Shoulder |
| Brock Bowers | TE | LV | 22 | Week 8 | Questionable | Knee |
| Ka'imi Fairbairn | PK | Hou | 31 | Week 6 | ||
| Carl Granderson | DL | NO | 28 | Week 11 | ||
| Chase Young | DL | NO | 26 | Week 11 | Questionable | Calf |
| Danielle Hunter | DL | Hou | 30 | Week 6 | ||
| Bobby Wagner | LB | Was | 35 | Week 12 | ||
| Fred Warner | LB | SF | 28 | Week 14 | ||
| Foyesade Oluokun | LB | Jac | 30 | Week 8 | Questionable | Illness |
| E.J. Speed | LB | Hou | 30 | Week 6 | ||
| Christian Elliss | LB | NE | N/A | Week 14 | Questionable | Shoulder |
| Tyrique Stevenson | CB | Chi | 25 | Week 5 | ||
| Byron Murphy | CB | Min | 27 | Week 6 | ||
| Trevon Moehrig | S | Car | 26 | Week 14 | ||
| Antoine Winfield | S | TB | 27 | Week 9 |