| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Jalon Walker | DL | Atl | 21 | Week 5 | ||
| James Pearce Jr. | DL | Atl | 21 | Week 5 | Groin | |
| Carson Schwesinger | LB | Cle | 22 | Week 9 | ||
| Jayden Higgins | WR | Hou | 22 | Week 6 | ||
| Jalen Milroe | QB | Sea | 22 | Week 8 | ||
| Jayden Daniels | QB | Was | 24 | Week 12 | ||
| Sam Darnold | QB | Sea | 28 | Week 8 | ||
| Aaron Jones | RB | Min | 30 | Week 6 | ||
| Trey Benson | RB | Ari | 23 | Week 8 | ||
| Kenneth Gainwell | RB | Pit | 26 | Week 5 | ||
| Jordan Mason | RB | Min | 26 | Week 6 | ||
| Chase Brown | RB | Cin | 25 | Week 10 | ||
| Emanuel Wilson | RB | GB | 26 | Week 5 | ||
| Josh Palmer | WR | Buf | 25 | Week 7 | ||
| Khalil Shakir | WR | Buf | 25 | Week 7 | ||
| Jordan Addison | WR | Min | 23 | Week 6 | Suspension | |
| Brian Thomas Jr. | WR | Jac | 22 | Week 8 | ||
| Marquise Brown | WR | KC | 28 | Week 10 | ||
| Jonnu Smith | TE | Pit | 30 | Week 5 | ||
| Brock Bowers | TE | LV | 22 | Week 8 | Questionable | Knee |
| Joshua Karty | PK | LAR | 23 | Week 8 | ||
| Jared Verse | DL | LAR | 24 | Week 8 | ||
| Rashan Gary | DL | GB | 27 | Week 5 | ||
| Brian Burns | DL | NYG | 27 | Week 14 | ||
| Will McDonald | DL | NYJ | N/A | Week 9 | ||
| Dre Greenlaw | LB | Den | 28 | Week 12 | Out | Quadriceps |
| Pete Werner | LB | NO | 26 | Week 11 | ||
| Edgerrin Cooper | LB | GB | 23 | Week 5 | ||
| Lavonte David | LB | TB | 35 | Week 9 | ||
| Jaire Alexander | CB | Bal | 28 | Week 7 | ||
| Zyon McCollum | CB | TB | N/A | Week 9 | ||
| Reed Blankenship | S | Phi | 26 | Week 9 | ||
| Derwin James | S | LAC | 29 | Week 12 |