| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Justin Herbert | QB | LAC | 26 | **** | ||
| Tommy DeVito | QB | NYG | N/A | **** | ||
| Emari Demercado | RB | Ari | 25 | **** | ||
| Michael Carter | RB | Ari | 24 | **** | ||
| Elijah Mitchell | RB | SF | 26 | **** | ||
| Khalil Herbert | RB | Chi | 26 | **** | ||
| James Robinson | RB | F/A | 25 | **** | ||
| Dameon Pierce | RB | Hou | 24 | **** | ||
| D'Ernest Johnson | RB | Jac | 28 | **** | ||
| Devin Singletary | RB | NYG | 26 | **** | ||
| Jerick McKinnon | RB | KC | 32 | **** | ||
| Aaron Jones | RB | Min | 29 | **** | ||
| Chase Edmonds | RB | TB | 28 | **** | ||
| Noah Brown | WR | Hou | N/A | **** | ||
| D.J. Moore | WR | Chi | 27 | **** | ||
| Tyreek Hill | WR | Mia | 30 | **** | ||
| Gabriel Davis | WR | Jac | 25 | **** | ||
| Xavier Gipson | WR | NYJ | N/A | **** | ||
| Ja'Marr Chase | WR | Cin | 24 | **** | ||
| Sam LaPorta | TE | Det | 23 | **** | ||
| Darren Waller | TE | NYG | 31 | **** | ||
| Brandon McManus | PK | Jac | 32 | **** | ||
| Carl Granderson | DL | NO | 27 | **** | ||
| Jonathan Greenard | DL | Min | N/A | **** | ||
| D.J. Wonnum | DL | Min | 26 | **** | ||
| Michael Hoecht | DL | LAR | N/A | **** | ||
| Jack Gibbens | LB | Ten | N/A | **** | ||
| Ivan Pace | LB | Min | 23 | **** | ||
| Robert Spillane | LB | LV | 28 | **** | ||
| Zach Cunningham | LB | Phi | 29 | **** | ||
| Trent McDuffie | CB | KC | N/A | **** | ||
| Jonathan Owens | S | Chi | 28 | **** |