| Position | Starters | Proteam | TW | PPG | Total | Breakdown |
|---|---|---|---|---|---|---|
| QB | Taysom Hill | NO | 26.3 | 9.64 | 86.80 | 175 Pass, 73 Rush, 2 TD |
| RB | Najee Harris | Pit | 23.9 | 16.23 | 211.00 | 94 Rush, 10 Receiving, 3 Rec, 2 TD |
| RB | Sony Michel | LAR | 7.9 | 6.27 | 81.50 | 79 Rush |
| WR | Chris Godwin | TB | 15.5 | 14.42 | 187.50 | 105 Receiving, 10 Rec |
| WR | CeeDee Lamb | Dal | 11.1 | 13.73 | 164.80 | 15 Rush, 61 Receiving, 7 Rec |
| WR | Courtland Sutton | Den | 1.4 | 7.98 | 103.80 | 9 Receiving, 1 Rec |
| TE | Ricky Seals-Jones | Was | 1.3 | 4.78 | 47.80 | 8 Receiving, 1 Rec |
| HB (RB) | Javonte Williams | Den | 20.8 | 11.86 | 154.20 | 73 Rush, 10 Receiving, 1 Rec, 2 TD |
| PK | Michael Badgley | Ind | DNP | 7.44 | 67.00 | Team had a Bye |
| DL | Nick Bosa | SF | 11.0 | 8.31 | 108.00 | 2 Tackles, 1 Assist, 2.0 Sacks |
| DL | Greg Gaines | LAR | 9.0 | 4.46 | 58.00 | 3 Tackles, 2 Assists, 1.0 Sack |
| DL | Myles Garrett | Cle | 19.0 | 9.31 | 121.00 | 3 Tackles, 1.0 Sack, 1 TD, 1 FF, 1 Fum Rcvy |
| LB | Jeremiah Owusu-Koramoah | Cle | 5.0 | 6.60 | 66.00 | 5 Tackles |
| LB | Germaine Pratt | Cin | 10.0 | 6.92 | 90.00 | 4 Tackles, 5 Assists, 1 PD |
| LB | Patrick Queen | Bal | 2.0 | 6.38 | 83.00 | 1 Tackle, 1 Assist |
| CB | Trevon Diggs | Dal | 5.0 | 9.00 | 117.00 | 1 Tackle, 1 Assist, 3 PD |
| S | Justin Simmons | Den | 12.0 | 7.69 | 100.00 | 5 Tackles, 1 Assist, 1 Int, 1 PD |
| Position | 1st Backups | Proteam | TW | PPG | Total | Breakdown |
| QB | Baker Mayfield | Cle | 0(19.0) | 15.58 | 186.92 | 190 Pass, 14 Rush, 2 TD, 1 Int |
| RB | Clyde Edwards-Helaire | KC | 0(17.7) | 11.56 | 92.50 | 37 Rush, 5 Receiving, 3 Rec, 2 TD |
| WR | Marquez Callaway | NO | 0(4.4) | 7.33 | 95.30 | 34 Receiving, 2 Rec |
| HB (RB) | D'Onta Foreman | Ten | 0(13.2) | 3.34 | 40.10 | 47 Rush, 15 Receiving, 2 Rec, 1 TD |
| DL | Greg Rousseau | Buf | 0(1.0) | 4.54 | 59.00 | 1 Tackle |
| LB | T.J. Edwards | Phi | DNP | 8.38 | 109.00 | Team had a Bye |
| S | Kyle Dugger | NE | DNP | 9.08 | 109.00 | Team had a Bye |
| Position | 2nd Backups | Proteam | TW | PPG | Total | Breakdown |
| QB | Jalen Hurts | Phi | DNP | 23.48 | 281.70 | Team had a Bye |
| RB | JaMycal Hasty | SF | 0(2.5) | 4.13 | 28.90 | 10 Receiving, 3 Rec |
| DL | Kwity Paye | Ind | DNP | 4.00 | 44.00 | Team had a Bye |
| Offense = 108.2 Defense = 73 Total = 181.2 | ||||||
| Position | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | Mike Davis | Atl | 0(11.1) | 7.58 | 98.60 | 44 Rush, 42 Receiving, 5 Rec |
| RB | Khalil Herbert | Chi | 0(0.3) | 4.28 | 55.70 | 3 Rush |
| RB | Boston Scott | Phi | DNP | 4.65 | 60.40 | Team had a Bye |
| WR | Jakobi Meyers | NE | DNP | 7.95 | 103.40 | Team had a Bye |
| WR | Laviska Shenault | Jac | 0(5.4) | 6.05 | 78.60 | 34 Receiving, 4 Rec |
| LB | Bobby Okereke | Ind | DNP | 9.31 | 121.00 | Team had a Bye |