| Position | Starters | Proteam | TW | PPG | Total | Breakdown |
|---|---|---|---|---|---|---|
| QB | Kyler Murray | Ari | 17.42 | 26.40 | 263.98 | 383 Pass, 61 Rush, 2 Int |
| RB | Melvin Gordon | Den | 23.1 | 12.61 | 151.30 | 111 Rush, 2 TD |
| RB | Mark Ingram | NO | DNP | 7.63 | 91.60 | Did Not Play |
| WR | Ja'Marr Chase | Cin | 22.8 | 14.97 | 194.60 | 6 Rush, 77 Receiving, 5 Rec, 2 TD |
| WR | Stefon Diggs | Buf | 10.9 | 13.71 | 178.20 | 74 Receiving, 7 Rec |
| WR | K.J. Osborn | Min | 15.8 | 7.19 | 93.50 | 83 Receiving, 3 Rec, 1 TD |
| TE | Noah Fant | Den | 7.1 | 7.67 | 92.00 | 51 Receiving, 4 Rec |
| HB (WR) | Odell Beckham | LAR | 16.7 | 7.90 | 79.00 | 77 Receiving, 6 Rec, 1 TD |
| PK | Ryan Succop | TB | 9.0 | 7.54 | 98.00 | 2 FG(<40), 3 XP |
| DL | Malcom Brown | Jac | 4.0 | 3.54 | 46.00 | 2 Tackles, 2 Assists |
| DL | Tanoh Kpassagnon | NO | DNP | 4.33 | 39.00 | Did Not Play |
| DL | Da'Ron Payne | Was | 10.0 | 4.62 | 60.00 | 5 Tackles, 1 Assist, 1.0 Sack |
| LB | Josh Allen | Jac | 2.0 | 7.31 | 95.00 | 2 Tackles |
| LB | Lavonte David | TB | 9.0 | 9.00 | 99.00 | 8 Tackles, 1 Assist |
| LB | Micah Parsons | Dal | 14.0 | 10.23 | 133.00 | 3 Tackles, 2.0 Sacks, 1 FF |
| CB | Anthony Brown | Dal | 3.0 | 7.69 | 100.00 | 2 Tackles, 1 PD |
| S | Andrew Wingard | Jac | 8.0 | 6.54 | 85.00 | 5 Tackles, 3 Assists |
| Position | 1st Backups | Proteam | TW | PPG | Total | Breakdown |
| QB | Joe Burrow | Cin | 0(26.22) | 21.58 | 280.52 | 348 Pass, 3 Rush, 2 TD |
| WR | A.J. Green | Ari | 0(13.7) | 8.70 | 104.40 | 102 Receiving, 7 Rec |
| TE | O.J. Howard | TB | 0(0.0) | 2.04 | 26.50 | Played, No Stats |
| HB (WR) | Marvin Jones | Jac | 0(10.0) | 8.15 | 106.00 | 70 Receiving, 6 Rec |
| LB | Zaven Collins | Ari | 0(0.0) | 2.00 | 22.00 | Played, No Stats |
| S | Jabrill Peppers | NYG | DNP | 6.17 | 37.00 | Did Not Play |
| Position | 2nd Backups | Proteam | TW | PPG | Total | Breakdown |
| QB | Tyrod Taylor | LAC | DNP | 15.29 | 91.74 | Did Not Play |
| RB | Jake Funk | LAR | 0.0 | 0.05 | 0.60 | Played, No Stats |
| WR | Anthony Miller | Pit | 0(0.0) | 1.28 | 11.50 | Played, No Stats |
| HB (WR) | Jamison Crowder | NYJ | 0(3.4) | 7.66 | 76.60 | 19 Receiving, 3 Rec |
| Offense = 122.82 Defense = 50 Total = 172.82 | ||||||
| Position | Bench | Proteam | TW | PPG | Total | Breakdown |
| HB (RB) | J.K. Dobbins | Bal | DNP | 0.00 | 0 | Did Not Play |
| HB (RB) | Royce Freeman | Hou | 0(9.6) | 2.08 | 22.90 | 15 Rush, 51 Receiving, 6 Rec |
| HB (RB) | Todd Gurley | F/A | DNP | 0.00 | 0.00 | Did Not Play |
| HB (RB) | Marlon Mack | Ind | DNP | 1.98 | 11.90 | Team had a Bye |
| HB (WR) | Robert Woods | LAR | DNP | 12.78 | 115.00 | Did Not Play |
| Position | Injured Reserve | Proteam | TW | PPG | Total | Breakdown |
| HB (RB) | Raheem Mostert | SF | DNP | 2.00 | 2.00 | Did Not Play |