| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Josh Allen | Buf | 21.16 | 26.66 | 426.58 | 169 Pass, 44 Rush, 2 TD, 1 Int |
| RB | Tony Pollard | Dal | 5.40 | 11.28 | 180.50 | 49 Rush, 1 Rec |
| RB | Devin Singletary | Hou | 10.10 | 8.83 | 141.34 | 80 Rush, 6 Receiving, 3 Rec |
| WR | Stefon Diggs | Buf | 5.10 | 13.07 | 209.10 | 5 Rush, 26 Receiving, 4 Rec |
| WR | Calvin Ridley | Jac | 5.90 | 10.77 | 172.30 | 39 Receiving, 4 Rec |
| WR | Darius Slayton | NYG | 18.60 | 6.96 | 111.30 | 106 Receiving, 4 Rec, 1 TD |
| TE | Dallas Goedert | Phi | 13.20 | 8.15 | 105.90 | 47 Receiving, 5 Rec, 1 TD |
| HB | K.J. Osborn | Min | 0.00 | 6.27 | 94.10 | Played, No Stats |
| PK | Nicholas Folk | Ten | 5.00 | 7.81 | 125.00 | 1 FG(50-59) |
| DL | Aaron Donald | LAR | 14.00 | 5.44 | 87.00 | 3 Tackles, 2 Assists, 2.0 Sacks, 1 PD |
| DL | Khalil Mack | LAC | 11.00 | 9.69 | 155.00 | 5 Tackles, 2 Assists, 1.0 Sack |
| DL | T.J. Watt | Pit | 2.00 | 10.50 | 168.00 | 1 Tackle, 1 Assist |
| LB | T.J. Edwards | Chi | 8.00 | 11.56 | 185.00 | 2 Tackles, 1 Int, 1 PD |
| LB | Patrick Queen | Bal | 7.00 | 9.63 | 154.00 | 3 Tackles, 3 Assists, 1 PD |
| LB | Bobby Wagner | Sea | 14.00 | 11.81 | 189.00 | 4 Tackles, 10 Assists |
| CB | Nate Hobbs | LV | 8.00 | 8.58 | 103.00 | 4 Tackles, 4 Assists |
| S | Jaquan Brisker | Chi | 5.00 | 8.71 | 122.00 | 4 Tackles, 1 Assist |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Gardner Minshew | Ind | 0(15.26) | 13.79 | 220.66 | 224 Pass, 3 Rush, 1 TD |
| WR | Jalin Hyatt | NYG | 0(4.00) | 2.99 | 47.80 | 25 Receiving, 3 Rec |
| TE | Cade Otton | TB | 0(2.00) | 5.63 | 90.00 | 10 Receiving, 2 Rec |
| TE | Hunter Henry | NE | DNP | 7.06 | 98.90 | Did Not Play |
| PK | Wil Lutz | Den | 0(11.00) | 7.75 | 124.00 | 2 FG(<40), 1 FG(40-49), 1 XP |
| DL | Dexter Lawrence | NYG | 0(2.00) | 4.80 | 72.00 | 2 Tackles |
| LB | Alex Anzalone | Det | 0(8.00) | 9.33 | 140.00 | 5 Tackles, 3 Assists |
| CB | Jalen Ramsey | Mia | 0(2.00) | 4.22 | 38.00 | 2 Tackles |
| S | Kevin Byard | Phi | 0(11.00) | 8.33 | 125.00 | 8 Tackles, 3 Assists |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| WR | Treylon Burks | Ten | 0(2.10) | 3.19 | 31.90 | 11 Receiving, 2 Rec |
| DL | Jalen Carter | Phi | 0(5.00) | 4.60 | 69.00 | 1 Tackle, 1.0 Sack |
| LB | Christian Harris | Hou | 0(7.00) | 6.87 | 103.00 | 3 Tackles, 2 Assists, 2 PD |
| S | Jamal Adams | Sea | 0 | 5.00 | 50.00 | Played, No Stats |
| Offense = 84.46 Defense = 69 Total = 153.46 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | Jerick McKinnon | KC | DNP | 6.16 | 73.96 | Did Not Play |
| WR | Christian Kirk | Jac | DNP | 10.31 | 123.76 | Did Not Play |
| S | Minkah Fitzpatrick | Pit | DNP | 6.70 | 67.00 | Did Not Play |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| QB | Anthony Richardson | Ind | DNP | 19.92 | 79.68 | Did Not Play |