| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Joe Burrow | Cin | 42.84 | 24.01 | 384.24 | 446 Pass, 10 Rush, 4 TD |
| RB | Austin Ekeler | LAC | 18.70 | 19.03 | 285.40 | 58 Rush, 54 Receiving, 3 Rec, 1 TD |
| RB | Jonathan Taylor | Ind | 17.90 | 21.51 | 344.10 | 108 Rush, 6 Receiving, 1 Rec, 1 TD |
| WR | D.K. Metcalf | Sea | 27.90 | 12.41 | 198.50 | 6 Rush, 63 Receiving, 6 Rec, 3 TD |
| WR | Deebo Samuel | SF | 15.70 | 18.37 | 275.50 | 19 Rush, 63 Receiving, 3 Rec, 1 TD |
| WR | Mike Williams | LAC | 13.80 | 12.41 | 186.20 | 63 Receiving, 3 Rec, 1 TD |
| TE | George Kittle | SF | 4.00 | 12.31 | 160.00 | 6 Rush, 29 Receiving, 1 Rec |
| HB | Jaret Patterson | Was | 18.30 | 2.90 | 46.40 | 57 Rush, 41 Receiving, 5 Rec, 1 TD |
| PK | Robbie Gould | SF | 11.00 | 8.42 | 101.00 | 3 FG(<40), 2 XP |
| DL | Myles Garrett | Cle | 1.00 | 7.88 | 126.00 | 1 Tackle |
| DL | Cameron Jordan | NO | 22.00 | 7.47 | 112.00 | 6 Tackles, 2 Assists, 3.5 Sacks |
| DL | Larry Ogunjobi | Cin | 4.00 | 4.81 | 77.00 | 3 Tackles, 1 Assist |
| LB | Anthony Barr | Min | 9.00 | 8.90 | 89.00 | 5 Tackles, 4 Assists |
| LB | Jordyn Brooks | Sea | 10.00 | 11.06 | 177.00 | 5 Tackles, 5 Assists |
| LB | Shaq Thompson | Car | 7.00 | 9.31 | 121.00 | 4 Tackles, 3 Assists |
| CB | Kendall Fuller | Was | 6.00 | 6.19 | 99.00 | 5 Tackles, 1 PD |
| S | Jalen Thompson | Ari | 6.00 | 8.19 | 131.00 | 3 Tackles, 3 Assists |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Davis Mills | Hou | 0(10.92) | 13.06 | 156.72 | 163 Pass, 4 Rush, 1 TD, 1 Int |
| RB | Devonta Freeman | Bal | 0(8.20) | 7.87 | 125.90 | 76 Rush, 1 Receiving, 1 Rec |
| WR | Odell Beckham | LAR | 0(12.40) | 8.02 | 104.30 | 39 Receiving, 5 Rec, 1 TD |
| TE | Brevin Jordan | Hou | 0(1.40) | 5.72 | 45.80 | 9 Receiving, 1 Rec |
| RB | Boston Scott | Phi | 0(22.60) | 5.82 | 93.10 | 47 Rush, 39 Receiving, 4 Rec, 2 TD |
| DL | Dorance Armstrong | Dal | 0(10.00) | 5.17 | 62.00 | 3 Tackles, 2 Assists, 1.0 Sack, 1 PD |
| LB | Patrick Queen | Bal | 0(1.00) | 6.69 | 107.00 | 1 Tackle |
| CB | James Bradberry | NYG | 0(8.00) | 5.69 | 91.00 | 1 Assist, 1 Int, 2 PD |
| S | Xavier Woods | Min | 0(8.00) | 8.50 | 136.00 | 7 Tackles, 1 Assist |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Taylor Heinicke | Was | 0(9.28) | 16.20 | 259.26 | 247 Pass, 14 Rush, 1 Int |
| RB | Saquon Barkley | NYG | 0(10.20) | 10.23 | 122.70 | 102 Rush |
| WR | Rashod Bateman | Bal | 0(9.30) | 7.03 | 77.30 | 58 Receiving, 7 Rec |
| WR | Van Jefferson | LAR | 0(8.30) | 8.69 | 139.10 | 63 Receiving, 4 Rec |
| LB | Cory Littleton | LV | 0 | 6.75 | 108.00 | Played, No Stats |
| Offense = 170.14 Defense = 65 Total = 235.14 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| QB | Deshaun Watson | Hou | DNP | 0.00 | 0.00 | Did Not Play |
| WR | Josh Palmer | LAC | 3.10 | 3.99 | 63.90 | 16 Receiving, 3 Rec |