| Position | Starters | Proteam | TW | PPG | Total | Breakdown |
|---|---|---|---|---|---|---|
| QB | Patrick Mahomes | KC | 24.86 | 25.59 | 409.46 | 259 Pass, 25 Rush, 2 TD |
| RB | Saquon Barkley | NYG | 10.2 | 10.23 | 122.70 | 102 Rush |
| RB | Joe Mixon | Cin | 12.1 | 16.74 | 267.90 | 46 Rush, 40 Receiving, 7 Rec |
| WR | Tyreek Hill | KC | 7.2 | 15.08 | 241.30 | 2 Rush, 40 Receiving, 6 Rec |
| WR | CeeDee Lamb | Dal | 6.6 | 12.52 | 187.80 | 51 Receiving, 3 Rec |
| WR | DeVonta Smith | Phi | 6.9 | 9.31 | 149.00 | 54 Receiving, 3 Rec |
| TE | Dallas Goedert | Phi | 10.1 | 9.13 | 137.00 | 71 Receiving, 6 Rec |
| HB (RB) | Darrel Williams | KC | 24.2 | 10.39 | 166.30 | 88 Rush, 19 Receiving, 3 Rec, 2 TD |
| PK | Robbie Gould | SF | 11 | 8.42 | 101.00 | 3 FG(<40), 2 XP |
| DL | Myles Garrett | Cle | 1 | 7.88 | 126.00 | 1 Tackle |
| DL | Jeffery Simmons | Ten | 1 | 5.56 | 89.00 | 1 Tackle |
| DL | Josh Sweat | Phi | 13 | 5.13 | 82.00 | 3 Tackles, 2 Assists, 1.5 Sacks, 2 PD |
| LB | Kamu Grugier-Hill | Hou | 7 | 9.92 | 129.00 | 5 Tackles, 2 Assists |
| LB | C.J. Mosley | NYJ | 13 | 11.40 | 171.00 | 7 Tackles, 6 Assists |
| LB | T.J. Watt | Pit | 23 | 12.29 | 172.00 | 5 Tackles, 4.0 Sacks, 2 PD |
| CB | Jalen Ramsey | LAR | 3 | 7.27 | 109.00 | 2 Tackles, 1 PD |
| S | Antoine Winfield | TB | 8 | 9.08 | 109.00 | 7 Tackles, 1 Assist |
| Position | 1st Backups | Proteam | TW | PPG | Total | Breakdown |
| QB | Jimmy Garoppolo | SF | DNP | 18.27 | 255.76 | Did Not Play |
| RB | Devontae Booker | NYG | 0(5.6) | 8.03 | 120.50 | 46 Rush, 2 Rec |
| WR | Braxton Berrios | NYJ | 0(22.7) | 6.23 | 99.70 | 12 Rush, 65 Receiving, 8 Rec, 2 TD, 1 Fumb |
| TE | Tyler Conklin | Min | 0(7.2) | 6.64 | 106.20 | 47 Receiving, 5 Rec |
| HB (RB) | Tony Pollard | Dal | 0(7.3) | 9.54 | 143.10 | 9 Rush, 49 Receiving, 3 Rec |
| DL | Chris Wormley | Pit | DNP | 5.21 | 73.00 | Did Not Play |
| LB | Isaiah Simmons | Ari | 0(13) | 8.06 | 129.00 | 8 Tackles, 2 Assists, 1 FF |
| CB | Taron Johnson | Buf | 0(8) | 6.67 | 100.00 | 3 Tackles, 1 Assist, 1.0 Sack |
| S | Vonn Bell | Cin | 0(6) | 7.88 | 126.00 | 2 Tackles, 3 Assists, 1 PD |
| Position | 2nd Backups | Proteam | TW | PPG | Total | Breakdown |
| QB | Chad Henne | KC | DNP | 0.82 | 3.28 | Did Not Play |
| RB | Samaje Perine | Cin | 0(1.9) | 4.65 | 69.70 | 4 Rush, 10 Receiving, 1 Rec |
| HB (RB) | Boston Scott | Phi | 0(22.6) | 5.82 | 93.10 | 47 Rush, 39 Receiving, 4 Rec, 2 TD |
| DL | Dorance Armstrong | Dal | 0(10) | 5.17 | 62.00 | 3 Tackles, 2 Assists, 1.0 Sack, 1 PD |
| Offense = 113.16 Defense = 69 Total = 182.16 | ||||||
| Position | Bench | Proteam | TW | PPG | Total | Breakdown |
| QB | Deshaun Watson | Hou | DNP | 0.00 | 0 | Did Not Play |
| RB | Clyde Edwards-Helaire | KC | DNP | 11.01 | 110.10 | Did Not Play |
| WR | Chris Godwin | TB | 0(0) | 13.03 | 195.40 | Played, No Stats |