| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Justin Fields | Chi | 8.62 | 20.48 | 266.18 | 148 Pass, 27 Rush |
| RB | Najee Harris | Pit | 21.80 | 10.71 | 182.00 | 112 Rush, 21 Receiving, 5 Rec, 1 TD |
| RB | Jonathan Taylor | Ind | 26.60 | 14.69 | 146.90 | 188 Rush, 8 Receiving, 2 Rec, 1 TD |
| WR | Gabriel Davis | Buf | 0.00 | 8.23 | 139.90 | Played, No Stats |
| WR | Tyreek Hill | Mia | 17.70 | 19.87 | 317.90 | 82 Receiving, 7 Rec, 1 TD |
| WR | Garrett Wilson | NYJ | 4.40 | 9.86 | 167.70 | 34 Receiving, 2 Rec |
| TE | Dalton Schultz | Hou | 6.70 | 8.13 | 122.00 | 42 Receiving, 5 Rec |
| HB | Jerry Jeudy | Den | 15.40 | 7.17 | 114.80 | 79 Receiving, 3 Rec, 1 TD |
| PK | Cameron Dicker | LAC | 15.00 | 8.88 | 151.00 | 1 FG(<40), 3 FG(40-49) |
| DL | Maxx Crosby | LV | 6.00 | 9.35 | 159.00 | 2 Tackles, 1.0 Sack |
| DL | Boye Mafe | Sea | 3.00 | 6.31 | 101.00 | 1 Tackle, 2 Assists |
| DL | Zach Sieler | Mia | 9.00 | 7.53 | 128.00 | 2 Tackles, 5 Assists, 0.5 Sack |
| LB | Zaire Franklin | Ind | 9.00 | 12.44 | 199.00 | 3 Tackles, 6 Assists |
| LB | Josey Jewell | Den | 13.00 | 8.63 | 138.00 | 6 Tackles, 3 Assists, 1.0 Sack |
| LB | Nate Landman | Atl | 13.00 | 8.50 | 136.00 | 5 Tackles, 5 Assists, 1 FF |
| CB | Taron Johnson | Buf | 9.00 | 7.12 | 121.00 | 4 Tackles, 5 Assists |
| S | Derwin James | LAC | 8.00 | 9.50 | 152.00 | 7 Tackles, 1 Assist |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Russell Wilson | Den | 0 | 18.46 | 313.86 | Played, No Stats |
| RB | Alexander Mattison | Min | 0(3.40) | 7.51 | 120.20 | 24 Rush, 5 Receiving, 1 Rec |
| WR | Amari Cooper | Cle | DNP | 0.00 | 0.00 | Did Not Play |
| TE | Cole Kmet | Chi | 0(5.60) | 8.51 | 144.60 | 41 Receiving, 3 Rec |
| RB | Jerome Ford | Cle | 0(4.20) | 11.07 | 188.20 | 6 Rush, 26 Receiving, 2 Rec |
| PK | Jake Elliott | Phi | 0(4.00) | 9.12 | 155.00 | 1 FG(<40), 1 XP |
| DL | Michael Hoecht | LAR | 0(10.00) | 6.47 | 110.00 | 5 Tackles, 1 Assist, 1.0 Sack |
| CB | Jason Pinnock | NYG | DNP | 7.56 | 121.00 | Did Not Play |
| S | Julian Blackmon | Ind | DNP | 0.00 | 0.00 | Did Not Play |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Nick Mullens | Min | 0(24.64) | 13.46 | 80.74 | 396 Pass, 8 Rush, 2 TD, 2 Int |
| TE | David Njoku | Cle | 0 | 9.57 | 162.70 | Played, No Stats |
| DL | George Karlaftis | KC | 0 | 5.59 | 95.00 | Played, No Stats |
| LB | Jordyn Brooks | Sea | 0(3.00) | 9.63 | 154.00 | 1 Tackle, 1 Assist, 1 PD |
| Offense = 116.22 Defense = 70 Total = 186.22 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | Christian McCaffrey | SF | DNP | 22.49 | 359.80 | Did Not Play |
| WR | Jonathan Mingo | Car | DNP | 4.22 | 63.30 | Did Not Play |
| LB | Roquan Smith | Bal | 0.00 | 10.53 | 179.00 | Played, No Stats |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| QB | Joe Burrow | Cin | DNP | 17.82 | 178.16 | Did Not Play |